BDBM50470579 4sc-202::Domatinostat

SMILES Cn1cc(cn1)-c1ccc(cc1)S(=O)(=O)n1ccc(\C=C\C(=O)Nc2ccccc2N)c1

InChI Key InChIKey=PRXXYMVLYKJITB-UHFFFAOYSA-N

Data  44 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 44 hits for monomerid = 50470579   

TargetHistone deacetylase 1(Human)
First Affiliated Hospital of Gannan Medical University

Curated by ChEMBL
LigandPNGBDBM50470579(4sc-202 | Domatinostat)
Affinity DataIC50: 1.20E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50470579(4sc-202 | Domatinostat)
Affinity DataIC50: 600nMAssay Description:Inhibition of LSD1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetHistone deacetylase 1(Human)
First Affiliated Hospital of Gannan Medical University

Curated by ChEMBL
LigandPNGBDBM50470579(4sc-202 | Domatinostat)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of human recombinant HDAC1 using fluorogenic HDAC substrate incubated for 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetHistone deacetylase 2(Human)
Xinxiang University

Curated by ChEMBL
LigandPNGBDBM50470579(4sc-202 | Domatinostat)
Affinity DataIC50: 1.12E+3nMAssay Description:Inhibition of human recombinant HDAC2 incubated for 60 mins by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetHistone deacetylase 3(Human)
Xinxiang University

Curated by ChEMBL
LigandPNGBDBM50470579(4sc-202 | Domatinostat)
Affinity DataIC50: 570nMAssay Description:Inhibition of human recombinant HDAC3 incubated for 60 mins by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50470579(4sc-202 | Domatinostat)
Affinity DataIC50: 600nMAssay Description:Inhibition of human N-terminal His-tagged LSD1 using histone H3 peptide (1 to 21 residues) K4me2 as substrate preincubated for 30 mins followed by su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetHistone deacetylase 1(Human)
First Affiliated Hospital of Gannan Medical University

Curated by ChEMBL
LigandPNGBDBM50470579(4sc-202 | Domatinostat)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of HDAC1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetHistone deacetylase 2(Human)
Xinxiang University

Curated by ChEMBL
LigandPNGBDBM50470579(4sc-202 | Domatinostat)
Affinity DataIC50: 1.12E+3nMAssay Description:Inhibition of HDAC2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetHistone deacetylase 3(Human)
Xinxiang University

Curated by ChEMBL
LigandPNGBDBM50470579(4sc-202 | Domatinostat)
Affinity DataIC50: 570nMAssay Description:Inhibition of HDAC3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50470579(4sc-202 | Domatinostat)
Affinity DataIC50: 600nMAssay Description:Inhibition of human LSD1 (unknown orgin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50470579(4sc-202 | Domatinostat)
Affinity DataIC50: 600nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetHistone deacetylase 11(Human)
Nirma University

Curated by ChEMBL
LigandPNGBDBM50470579(4sc-202 | Domatinostat)
Affinity DataIC50: 9.70E+3nMAssay Description:Inhibition of HDAC11 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetHistone deacetylase 2(Human)
Xinxiang University

Curated by ChEMBL
LigandPNGBDBM50470579(4sc-202 | Domatinostat)
Affinity DataIC50: 1.12E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetHistone deacetylase 3(Human)
Xinxiang University

Curated by ChEMBL
LigandPNGBDBM50470579(4sc-202 | Domatinostat)
Affinity DataIC50: 570nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetHistone deacetylase 1(Human)
First Affiliated Hospital of Gannan Medical University

Curated by ChEMBL
LigandPNGBDBM50470579(4sc-202 | Domatinostat)
Affinity DataIC50: 1.20E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHistone deacetylase 2(Human)
Xinxiang University

Curated by ChEMBL
LigandPNGBDBM50470579(4sc-202 | Domatinostat)
Affinity DataIC50: 1.10E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHistone deacetylase 3(Human)
Xinxiang University

Curated by ChEMBL
LigandPNGBDBM50470579(4sc-202 | Domatinostat)
Affinity DataIC50: 600nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50470579(4sc-202 | Domatinostat)
Affinity DataIC50: 600nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHistone deacetylase 2(Human)
Xinxiang University

Curated by ChEMBL
LigandPNGBDBM50470579(4sc-202 | Domatinostat)
Affinity DataIC50: 370nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetHistone deacetylase 1(Human)
First Affiliated Hospital of Gannan Medical University

Curated by ChEMBL
LigandPNGBDBM50470579(4sc-202 | Domatinostat)
Affinity DataIC50: 160nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50470579(4sc-202 | Domatinostat)
Affinity DataIC50: 1.20E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetHistone deacetylase 3(Human)
Xinxiang University

Curated by ChEMBL
LigandPNGBDBM50470579(4sc-202 | Domatinostat)
Affinity DataIC50: 130nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetHistone deacetylase 6(Human)
University of East Anglia

Curated by ChEMBL
LigandPNGBDBM50470579(4sc-202 | Domatinostat)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of HDAC6 (unknown origin) using p53 residues (379 to 382)(RHKK(Ac)-AMC) as substrate by fluorescent methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
First Affiliated Hospital of Gannan Medical University

Curated by ChEMBL
LigandPNGBDBM50470579(4sc-202 | Domatinostat)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of HDAC1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50470579(4sc-202 | Domatinostat)
Affinity DataIC50: 600nMAssay Description:Inhibition of KDM1A/LSD1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
First Affiliated Hospital of Gannan Medical University

Curated by ChEMBL
LigandPNGBDBM50470579(4sc-202 | Domatinostat)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of HDAC1 (unknown origin) using p53 residues (379 to 382)(RHKK(Ac)-AMC) as substrate by fluorescent methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetHistone deacetylase 2(Human)
Xinxiang University

Curated by ChEMBL
LigandPNGBDBM50470579(4sc-202 | Domatinostat)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of HDAC2 (unknown origin) using p53 residues (379 to 382)(RHKK(Ac)-AMC) as substrate by fluorescent methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetHistone deacetylase 3(Human)
Xinxiang University

Curated by ChEMBL
LigandPNGBDBM50470579(4sc-202 | Domatinostat)
Affinity DataIC50: 600nMAssay Description:Inhibition of HDAC3 (unknown origin) using p53 residues (379 to 382)(RHKK(Ac)-AMC) as substrate by fluorescent methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetHistone deacetylase 8(Human)
University of East Anglia

Curated by ChEMBL
LigandPNGBDBM50470579(4sc-202 | Domatinostat)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of HDAC8 (unknown origin) using p53 (379 to 382 residues)(RHK(Ac)K(ac)AMC) as substrate by fluorescent methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetHistone deacetylase 4(Human)
University of East Anglia

Curated by ChEMBL
LigandPNGBDBM50470579(4sc-202 | Domatinostat)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of HDAC4 (unknown origin) using HDAC class IIa substrate (trifluoroacetyl-lysine-AMC) as substrate by fluorescent methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetHistone deacetylase 5(Human)
University of East Anglia

Curated by ChEMBL
LigandPNGBDBM50470579(4sc-202 | Domatinostat)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of HDAC5 (unknown origin) using HDAC class IIa substrate (trifluoroacetyl-lysine-AMC) as substrate by fluorescent methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetHistone deacetylase 7(Human)
University of East Anglia

Curated by ChEMBL
LigandPNGBDBM50470579(4sc-202 | Domatinostat)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of HDAC7 (unknown origin) using HDAC class IIa substrate (trifluoroacetyl-lysine-AMC) as substrate by fluorescent methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetHistone deacetylase 9(Human)
University of East Anglia

Curated by ChEMBL
LigandPNGBDBM50470579(4sc-202 | Domatinostat)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of HDAC9 (unknown origin) using HDAC class IIa substrate (trifluoroacetyl-lysine-AMC) as substrate by fluorescent methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetHistone deacetylase 3(Human)
Xinxiang University

Curated by ChEMBL
LigandPNGBDBM50470579(4sc-202 | Domatinostat)
Affinity DataIC50: 130nMAssay Description:Inhibition of HDAC3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2020
Entry Details Article
PubMed
TargetPolyamine deacetylase HDAC10(Human)
University of East Anglia

Curated by ChEMBL
LigandPNGBDBM50470579(4sc-202 | Domatinostat)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of HDAC10 (unknown origin) using p53 residues (379 to 382)(RHKK(Ac)-AMC) as substrate by fluorescent methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetHistone deacetylase 11(Human)
Nirma University

Curated by ChEMBL
LigandPNGBDBM50470579(4sc-202 | Domatinostat)
Affinity DataIC50: 9.70E+3nMAssay Description:Inhibition of HDAC11 (unknown origin) using p53 (379 to 382 residues)(RHKK(Ac)-AMC) as substrate by fluorescent methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
First Affiliated Hospital of Gannan Medical University

Curated by ChEMBL
LigandPNGBDBM50470579(4sc-202 | Domatinostat)
Affinity DataIC50: 0.160nMAssay Description:Inhibition of HDAC1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetHistone deacetylase 2(Human)
Xinxiang University

Curated by ChEMBL
LigandPNGBDBM50470579(4sc-202 | Domatinostat)
Affinity DataIC50: 370nMAssay Description:Inhibition of HDAC2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetHistone deacetylase 3(Human)
Xinxiang University

Curated by ChEMBL
LigandPNGBDBM50470579(4sc-202 | Domatinostat)
Affinity DataIC50: 130nMAssay Description:Inhibition of HDAC3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetHistone deacetylase 1(Human)
First Affiliated Hospital of Gannan Medical University

Curated by ChEMBL
LigandPNGBDBM50470579(4sc-202 | Domatinostat)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of HDAC1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetHistone deacetylase 2(Human)
Xinxiang University

Curated by ChEMBL
LigandPNGBDBM50470579(4sc-202 | Domatinostat)
Affinity DataIC50: 1.12E+3nMAssay Description:Inhibition of HDAC2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetHistone deacetylase 3(Human)
Xinxiang University

Curated by ChEMBL
LigandPNGBDBM50470579(4sc-202 | Domatinostat)
Affinity DataIC50: 570nMAssay Description:Inhibition of HDAC3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetHistone deacetylase 9(Human)
University of East Anglia

Curated by ChEMBL
LigandPNGBDBM50470579(4sc-202 | Domatinostat)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of HDAC9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetPolyamine deacetylase HDAC10(Human)
University of East Anglia

Curated by ChEMBL
LigandPNGBDBM50470579(4sc-202 | Domatinostat)
Affinity DataIC50: 2.10E+4nMAssay Description:Inhibition of HDAC10 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed