BDBM27503 5-AIQ::5-amino-1,2-dihydroisoquinolin-1-one::5-aminoisoquinolin-1(2H)-one::CHEMBL446240

SMILES Nc1cccc2c1cc[nH]c2=O

InChI Key InChIKey=SVASVGVAQIVSEZ-UHFFFAOYSA-N

Data  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 27503   

TargetPoly [ADP-ribose] polymerase 1(Bovine)
University of Bath

Curated by ChEMBL
LigandPNGBDBM27503(5-amino-1,2-dihydroisoquinolin-1-one | CHEMBL44624...)
Affinity DataIC50: 250nMAssay Description:Inhibition of calf thymus PARP-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
University of Bath

Curated by ChEMBL
LigandPNGBDBM27503(5-amino-1,2-dihydroisoquinolin-1-one | CHEMBL44624...)
Affinity DataIC50: 300nMAssay Description:Inhibition of PARP-1 (unknown origin) in broken nuclear preparationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 2(Mouse)
University of Bath

Curated by ChEMBL
LigandPNGBDBM27503(5-amino-1,2-dihydroisoquinolin-1-one | CHEMBL44624...)
Affinity DataIC50: 1.05E+3nMAssay Description:Inhibition of mouse PARP-2More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
University of Bath

Curated by ChEMBL
LigandPNGBDBM27503(5-amino-1,2-dihydroisoquinolin-1-one | CHEMBL44624...)
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of human PARP-1 assessed as synthesis of [3H]-ADP-ribose polymers from [3H]-NAD+ by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
University of Bath

Curated by ChEMBL
LigandPNGBDBM27503(5-amino-1,2-dihydroisoquinolin-1-one | CHEMBL44624...)
Affinity DataIC50: 1.18E+3nMpH: 7.8 T: 2°CAssay Description:The enzymatic reaction of the recombinant PARP was quantified by SPA. Radioactivity incorporated from [3H]NAD+ into PAR, and then being captured by P...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/9/2009
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 2(Mouse)
University of Bath

Curated by ChEMBL
LigandPNGBDBM27503(5-amino-1,2-dihydroisoquinolin-1-one | CHEMBL44624...)
Affinity DataIC50: 1.82E+3nMpH: 7.8 T: 2°CAssay Description:The enzymatic reaction of the recombinant PARP was quantified by SPA. Radioactivity incorporated from [3H]NAD+ into PAR, and then being captured by P...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/9/2009
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
University of Bath

Curated by ChEMBL
LigandPNGBDBM27503(5-amino-1,2-dihydroisoquinolin-1-one | CHEMBL44624...)
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of human recombinant PARP1 by Trevigen colorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Bovine)
University of Bath

Curated by ChEMBL
LigandPNGBDBM27503(5-amino-1,2-dihydroisoquinolin-1-one | CHEMBL44624...)
Affinity DataIC50: 240nMAssay Description:Inhibition of calf thymus PARP1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
University of Bath

Curated by ChEMBL
LigandPNGBDBM27503(5-amino-1,2-dihydroisoquinolin-1-one | CHEMBL44624...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of full length human PARP-1 after 10 mins by FlashPlate scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 2(Mouse)
University of Bath

Curated by ChEMBL
LigandPNGBDBM27503(5-amino-1,2-dihydroisoquinolin-1-one | CHEMBL44624...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of recombinant full length mouse PARP-2 after 10 mins using [3H]NAD+ by solution-phase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
University of Bath

Curated by ChEMBL
LigandPNGBDBM27503(5-amino-1,2-dihydroisoquinolin-1-one | CHEMBL44624...)
Affinity DataIC50: 940nMAssay Description:Inhibition of full length human PARP-1 after 10 mins by FlashPlate scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 2(Mouse)
University of Bath

Curated by ChEMBL
LigandPNGBDBM27503(5-amino-1,2-dihydroisoquinolin-1-one | CHEMBL44624...)
Affinity DataIC50: 1.05E+3nMAssay Description:Inhibition of recombinant full length mouse PARP-2 after 10 mins using [3H]NAD+ by solution-phase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed