BDBM50331288 2-(5-bromo-1H-indol-3-yl)ethanamine::5-Br-T::CHEMBL1288717

SMILES NCCc1c[nH]c2ccc(Br)cc12

InChI Key InChIKey=CGHUQJRRADEHTQ-UHFFFAOYSA-N

Data  5 KI  2 IC50  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50331288   

TargetSodium-dependent serotonin transporter(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50331288(CHEMBL1288717 | 5-Br-T | 2-(5-bromo-1H-indol-3-yl)...)
Affinity DataEC50:  75nMAssay Description:Induction of 5-HTT-mediated 5-HT release in rat brain synaptosomes by [3H]5-HT release assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2016
Entry Details Article
PubMed
TargetTransporter(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50331288(CHEMBL1288717 | 5-Br-T | 2-(5-bromo-1H-indol-3-yl)...)
Affinity DataEC50: >1.00E+4nMAssay Description:Induction of NET-mediated norepinephrine release in rat brain synaptosomes by [3H]NE release assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2016
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50331288(CHEMBL1288717 | 5-Br-T | 2-(5-bromo-1H-indol-3-yl)...)
Affinity DataEC50:  478nMAssay Description:Induction of DAT-mediated dopamine release in rat brain synaptosomes by [3H]DA release assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2016
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50331288(CHEMBL1288717 | 5-Br-T | 2-(5-bromo-1H-indol-3-yl)...)
Affinity DataEC50:  5.10nMAssay Description:Agonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2016
Entry Details Article
PubMed
LigandPNGBDBM50331288(CHEMBL1288717 | 5-Br-T | 2-(5-bromo-1H-indol-3-yl)...)
Affinity DataIC50: 2.27E+4nMAssay Description:Antagonist activity at human TRPM8 receptor expressed in human T-REx-293 cells assessed as inhibition of menthol-induced 45calcium influx treated 5 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
LigandPNGBDBM50331288(CHEMBL1288717 | 5-Br-T | 2-(5-bromo-1H-indol-3-yl)...)
Affinity DataIC50: 3.04E+4nMAssay Description:Antagonist activity at human TRPM8 receptor expressed in human T-REx-293 cells assessed as inhibition of icilin-induced 45calcium influx treated 5 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
Eli Lilly

Curated by PDSP Ki Database
LigandPNGBDBM50331288(CHEMBL1288717 | 5-Br-T | 2-(5-bromo-1H-indol-3-yl)...)
Affinity DataKi:  13.9nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2012
Entry Details
PubMed
Target5-hydroxytryptamine receptor 2B(Rat)
University of Alberta

Curated by PDSP Ki Database
LigandPNGBDBM50331288(CHEMBL1288717 | 5-Br-T | 2-(5-bromo-1H-indol-3-yl)...)
Affinity DataKi:  38.9nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2B(Rat)
University of Alberta

Curated by PDSP Ki Database
LigandPNGBDBM50331288(CHEMBL1288717 | 5-Br-T | 2-(5-bromo-1H-indol-3-yl)...)
Affinity DataKi:  39.3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2012
Entry Details
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Eli Lilly

Curated by PDSP Ki Database
LigandPNGBDBM50331288(CHEMBL1288717 | 5-Br-T | 2-(5-bromo-1H-indol-3-yl)...)
Affinity DataKi:  1.52E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2012
Entry Details
PubMed
LigandPNGBDBM50331288(CHEMBL1288717 | 5-Br-T | 2-(5-bromo-1H-indol-3-yl)...)
Affinity DataKi:  3.25E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2012
Entry Details
PubMed