BDBM50318456 4-methoxy-N-(2,2,2-trichloro-1-(4-chlorophenylthio)ethyl)benzamide::AMG-5445::CHEMBL1086586

SMILES COc1ccc(cc1)C(=O)NC(Sc1ccc(Cl)cc1)C(Cl)(Cl)Cl

InChI Key InChIKey=MRIRDTYIRGDISF-UHFFFAOYSA-N

Data  3 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50318456   

LigandPNGBDBM50318456(AMG-5445 | 4-methoxy-N-(2,2,2-trichloro-1-(4-chlor...)
Affinity DataIC50: 91nMAssay Description:Antagonist activity at human TRPA1 channel assessed as inhibition of allyl isothiocyanate-induced intracellular calcium influxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
LigandPNGBDBM50318456(AMG-5445 | 4-methoxy-N-(2,2,2-trichloro-1-(4-chlor...)
Affinity DataIC50: 260nMAssay Description:Antagonist activity at human TRPA1 channel assessed as inhibition of allyl isothiocyanate-induced currentsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
LigandPNGBDBM50318456(AMG-5445 | 4-methoxy-N-(2,2,2-trichloro-1-(4-chlor...)
Affinity DataIC50: 29nMAssay Description:Antagonist activity at human TRPA1 channel assessed as inhibition of noxious cold-induced receptor activationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
LigandPNGBDBM50318456(AMG-5445 | 4-methoxy-N-(2,2,2-trichloro-1-(4-chlor...)
Affinity DataEC50:  115nMAssay Description:Agonist activity at TRPA1 channel in rat DRG neurons assessed as increase in intracellular calcium influxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed