BDBM50318455 AMG-9090::CHEMBL1086371::N-(2,2,2-trichloro-1-(4-chlorophenylthio)ethyl)benzamide

SMILES Clc1ccc(SC(NC(=O)c2ccccc2)C(Cl)(Cl)Cl)cc1

InChI Key InChIKey=NOXDIPWNQOTUAB-UHFFFAOYSA-N

Data  3 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50318455   

LigandPNGBDBM50318455(AMG-9090 | N-(2,2,2-trichloro-1-(4-chlorophenylthi...)
Affinity DataIC50: 21nMAssay Description:Antagonist activity at human TRPA1 channel assessed as inhibition of allyl isothiocyanate-induced intracellular calcium influxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
LigandPNGBDBM50318455(AMG-9090 | N-(2,2,2-trichloro-1-(4-chlorophenylthi...)
Affinity DataIC50: 120nMAssay Description:Antagonist activity at human TRPA1 channel assessed as inhibition of allyl isothiocyanate-induced currentsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
LigandPNGBDBM50318455(AMG-9090 | N-(2,2,2-trichloro-1-(4-chlorophenylthi...)
Affinity DataIC50: 7nMAssay Description:Antagonist activity at human TRPA1 channel assessed as inhibition of noxious cold-induced receptor activationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
LigandPNGBDBM50318455(AMG-9090 | N-(2,2,2-trichloro-1-(4-chlorophenylthi...)
Affinity DataEC50:  66nMAssay Description:Agonist activity at TRPA1 channel in rat DRG neurons assessed as increase in intracellular calcium influxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed