BDBM32144 8-quinolinamine::8-quinolylamine::AS-232::US10005735, Table 1.2::US9394254, 18::cid_11359::quinolin-8-amine

SMILES c1cc2cccnc2c(c1)N

InChI Key InChIKey=WREVVZMUNPAPOV-UHFFFAOYSA-N

Data  1 KI  5 IC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 32144   

TargetHeat shock protein HSP 90-alpha(Human)
Emory University

Curated by PubChem BioAssay
LigandPNGBDBM32144(cid_11359 | AS-232 | quinolin-8-amine | 8-quinolin...)
Affinity DataIC50: 5.00E+4nMpH: 7.4 T: 2°CAssay Description:A fluorescence polarization based HTS assay has been developed and optimized for the identification of Hsp90 inhibitors by using tumor cell lysate Hs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2009
Entry Details
PCBioAssay
TargetHeat shock protein HSP 90-alpha(Human)
Emory University

Curated by PubChem BioAssay
LigandPNGBDBM32144(cid_11359 | AS-232 | quinolin-8-amine | 8-quinolin...)
Affinity DataIC50: 5.00E+4nMpH: 7.4 T: 2°CAssay Description:A fluorescence polarization based HTS assay has been developed and optimized for the identification of Hsp90 inhibitors by using tumor cell lysate Hs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2009
Entry Details
PCBioAssay
TargetFructose-bisphosphate aldolase(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
The University of Denver and Regis University

US Patent
LigandPNGBDBM32144(cid_11359 | AS-232 | quinolin-8-amine | 8-quinolin...)
Affinity DataIC50: 7.90E+4nMAssay Description:Enzymatic activity is measured by contacting the enzyme with a suitable substrate, such as fructose 1,6-bisphosphate, and measuring formation of a pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2017
Entry Details
Go to US Patent

Target26S proteasome non-ATPase regulatory subunit 14(Human)
University of California San Diego

Curated by ChEMBL
LigandPNGBDBM32144(cid_11359 | AS-232 | quinolin-8-amine | 8-quinolin...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of 26S proteasome regulatory subunit RPN11 deubiquitinating activity in human erythrocytes using Ub4-pepOG protein substrate preincubated ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/4/2020
Entry Details Article
PubMed
Target26S proteasome non-ATPase regulatory subunit 14(Human)
University of California San Diego

Curated by ChEMBL
LigandPNGBDBM32144(cid_11359 | AS-232 | quinolin-8-amine | 8-quinolin...)
Affinity DataIC50: 1.00E+5nMAssay Description:In brief, this Rpn11 bioassay employs a fluorescent polarization readout based on the ability of the 26S proteasome to cleave the protein substrate i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/18/2020
Entry Details
Go to US Patent

TargetNeutrophil cytosol factor 1(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM32144(cid_11359 | AS-232 | quinolin-8-amine | 8-quinolin...)
Affinity DataKi: >2.00E+6nMAssay Description:Covalent inhibition of recombinant human His-tagged p47phox SH3A-B domain (151 to 285 residues) expressed in Escherichia coli BL21 (DE3) cells intera...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed