BDBM85550 Ang IV::CAS_12676-15-2::CHEMBL261120::cid_123814

SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(O)=O

InChI Key InChIKey=QSBGWDDCOJYQGY-UHFFFAOYSA-N

Data  15 KI  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 19 hits for monomerid = 85550   

TargetM17 leucyl aminopeptidase(Plasmodium falciparum (isolate 3D7))
Srmlsc

Curated by PubChem BioAssay
LigandPNGBDBM85550(cid_123814 | CHEMBL261120 | CAS_12676-15-2 | Ang I...)
Affinity DataIC50: 1.53E+3nMAssay Description:Southern Research Molecular Libraries Screening Center (SRMLSC) Southern Research Institute (Birmingham, Alabama) NIH Molecular Libraries Screening...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2011
Entry Details
PCBioAssay
TargetEndoplasmic reticulum aminopeptidase 1(Human)
National Center For Scientific Research Demokritos

Curated by ChEMBL
LigandPNGBDBM85550(cid_123814 | CHEMBL261120 | CAS_12676-15-2 | Ang I...)
Affinity DataIC50: 7.94E+4nMAssay Description:Inhibition of ERAP1 (unknown origin) using Leu-AMC as substrate by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetInterleukin-1 receptor antagonist protein(Human)
National Center For Scientific Research Demokritos

Curated by ChEMBL
LigandPNGBDBM85550(cid_123814 | CHEMBL261120 | CAS_12676-15-2 | Ang I...)
Affinity DataIC50: 251nMAssay Description:Inhibition of human IRAP soluble domain expressed in HEK293S GnTI(-) cells using Leu-AMC as substrate incubated for 2 hrs by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetEndoplasmic reticulum aminopeptidase 2(Human)
National Center For Scientific Research Demokritos

Curated by ChEMBL
LigandPNGBDBM85550(cid_123814 | CHEMBL261120 | CAS_12676-15-2 | Ang I...)
Affinity DataIC50: 7.94E+3nMAssay Description:Inhibition of ERAP2 (unknown origin) using Arg-AMC as substrate by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetAngiotensin-converting enzyme 2(Bovine)
Washington State University

Curated by PDSP Ki Database
LigandPNGBDBM85550(cid_123814 | CHEMBL261120 | CAS_12676-15-2 | Ang I...)
Affinity DataKi:  3.58nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/14/2012
Entry Details
PubMed
TargetAngiotensin-converting enzyme 2(Bovine)
Washington State University

Curated by PDSP Ki Database
LigandPNGBDBM85550(cid_123814 | CHEMBL261120 | CAS_12676-15-2 | Ang I...)
Affinity DataKi:  3.58nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/14/2012
Entry Details
PubMed
TargetAngiotensin-converting enzyme 2(Bovine)
Washington State University

Curated by PDSP Ki Database
LigandPNGBDBM85550(cid_123814 | CHEMBL261120 | CAS_12676-15-2 | Ang I...)
Affinity DataKi:  5.54nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/14/2012
Entry Details
PubMed
TargetAngiotensin-converting enzyme 2(Bovine)
Washington State University

Curated by PDSP Ki Database
LigandPNGBDBM85550(cid_123814 | CHEMBL261120 | CAS_12676-15-2 | Ang I...)
Affinity DataKi:  5.54nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/14/2012
Entry Details
PubMed
TargetLeucyl-cystinyl aminopeptidase(Human)
Uppsala University

Curated by ChEMBL
LigandPNGBDBM85550(cid_123814 | CHEMBL261120 | CAS_12676-15-2 | Ang I...)
Affinity DataKi:  7nMAssay Description:Displacement of [125I]Angiotensin 4 from human recombinant IRAP expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetLeucyl-cystinyl aminopeptidase(Human)
Uppsala University

Curated by ChEMBL
LigandPNGBDBM85550(cid_123814 | CHEMBL261120 | CAS_12676-15-2 | Ang I...)
Affinity DataKi:  56nMAssay Description:Inhibition of human recombinant IRAP expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2020
Entry Details Article
PubMed
TargetAminopeptidase N(Human)
Vrije Universiteit Brussel

Curated by ChEMBL
LigandPNGBDBM85550(cid_123814 | CHEMBL261120 | CAS_12676-15-2 | Ang I...)
Affinity DataKi:  56.2nMAssay Description:Inhibition of catalytic activity of human aminopeptidase N transfected in HEK293 cells assessed as formation of p-nitroanilineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetLeucyl-cystinyl aminopeptidase(Human)
Uppsala University

Curated by ChEMBL
LigandPNGBDBM85550(cid_123814 | CHEMBL261120 | CAS_12676-15-2 | Ang I...)
Affinity DataKi:  60nMAssay Description:Inhibition of human recombinant IRAP expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetLeucyl-cystinyl aminopeptidase(Human)
Uppsala University

Curated by ChEMBL
LigandPNGBDBM85550(cid_123814 | CHEMBL261120 | CAS_12676-15-2 | Ang I...)
Affinity DataKi:  62.4nMAssay Description:Inhibition of catalytic activity of recombinant human IRAP transfected in human HEK-293 cells assessed as cleavage of substrate L-leucine-p-nitroanil...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2011
Entry Details Article
PubMed
TargetType-1 angiotensin II receptor(Human)
Vrije Universiteit Brussel

Curated by ChEMBL
LigandPNGBDBM85550(cid_123814 | CHEMBL261120 | CAS_12676-15-2 | Ang I...)
Affinity DataKi:  407nMAssay Description:Displacement of [3H]valsartan from human AT1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2020
Entry Details Article
PubMed
TargetType-1 angiotensin II receptor(Human)
Vrije Universiteit Brussel

Curated by ChEMBL
LigandPNGBDBM85550(cid_123814 | CHEMBL261120 | CAS_12676-15-2 | Ang I...)
Affinity DataKi:  407nMAssay Description:Displacement of [3H]valsartan from human recombinant AT1 receptor expressed in CHO cells after 40 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetAminopeptidase N(Human)
Vrije Universiteit Brussel

Curated by ChEMBL
LigandPNGBDBM85550(cid_123814 | CHEMBL261120 | CAS_12676-15-2 | Ang I...)
Affinity DataKi:  830nMAssay Description:Inhibition of human recombinant APN expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAminopeptidase N(Human)
Vrije Universiteit Brussel

Curated by ChEMBL
LigandPNGBDBM85550(cid_123814 | CHEMBL261120 | CAS_12676-15-2 | Ang I...)
Affinity DataKi:  831nMAssay Description:Inhibition of human recombinant APN expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2020
Entry Details Article
PubMed
TargetLeucyl-cystinyl aminopeptidase(Human)
Uppsala University

Curated by ChEMBL
LigandPNGBDBM85550(cid_123814 | CHEMBL261120 | CAS_12676-15-2 | Ang I...)
Affinity DataKi:  832nMAssay Description:Inhibition of catalytic activity of human IRAP transfected in HEK293 cells assessed as formation of p-nitroanilineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetAminopeptidase N(Human)
Vrije Universiteit Brussel

Curated by ChEMBL
LigandPNGBDBM85550(cid_123814 | CHEMBL261120 | CAS_12676-15-2 | Ang I...)
Affinity DataKi:  841nMAssay Description:Inhibition of catalytic activity of recombinant human AP-N transfected in human HEK-293 cells assessed as cleavage of substrate L-leucine-p-nitroanil...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2011
Entry Details Article
PubMed