BDBM50372524 BAY-11-7082::CHEMBL403183

SMILES Cc1ccc(cc1)S(=O)(=O)/C=C/C#N

InChI Key InChIKey=DOEWDSDBFRHVAP-UHFFFAOYSA-N

Data  6 IC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50372524   

TargetTranscription factor p65(Human)
Columbia University

Curated by ChEMBL
LigandPNGBDBM50372524(BAY-11-7082 | CHEMBL403183)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of TNF-alpha-stimulated human NF-kappaB p65 RelA subunit nuclear translocation in HUVECMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Mouse)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50372524(BAY-11-7082 | CHEMBL403183)
Affinity DataIC50: 1.20E+4nMAssay Description:Inhibition of NLRP3 inflammasome activation in LPS-primed mouse NG5 cells assessed as reduction in IL-1beta level incubated for 15followed by additio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetSortase family protein(Staphylococcus aureus)
Mahidol University

Curated by ChEMBL
LigandPNGBDBM50372524(BAY-11-7082 | CHEMBL403183)
Affinity DataIC50: 1.29E+5nMAssay Description:Inhibition of Staphylococcus aureus sortase A using Abz/Dnp fluorescent peptide as a substrate measured after 30 mins by fluorescent based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Mouse)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50372524(BAY-11-7082 | CHEMBL403183)
Affinity DataIC50: 1.54E+3nMAssay Description:Inhibition of NLRP3 in mouse J774A.1 cells assessed as reduction of IL-1beta productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Mouse)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50372524(BAY-11-7082 | CHEMBL403183)
Affinity DataIC50: 1.20E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Mouse)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50372524(BAY-11-7082 | CHEMBL403183)
Affinity DataIC50: 1.54E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed