BDBM102888 US8541572, 2281

SMILES COc1ccc2CN(C[C@]3(NC(=O)NC3=O)C#Cc3ccc(CC4(C)NC(=O)NC4=O)cc3)C(=O)c2c1

InChI Key InChIKey=RPIXUTROJMVGDZ-UHFFFAOYSA-N

Data  1 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 102888   

TargetTumor necrosis factor(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM102888(US8541572, 2281)
Affinity DataKi:  0.540nM IC50: 1.00E+3nMAssay Description:Inhibition assay using TNF-alpha.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2013
Entry Details
US Patent

TargetPoly [ADP-ribose] polymerase 1(Human)
Chengdu Diao Pharmaceutical Group

US Patent
LigandPNGBDBM102888(US8541572, 2281)
Affinity DataIC50: 12nMT: 2°CAssay Description:The kit is based on ELISA. 10 μl sample/well, 15 μl PARP enzyme/well and PARP cocktail 25 μl/well with a total volume of 50 μl/we...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/16/2018
Entry Details
US Patent