BDBM103856 US9695165, 39

SMILES CCn1c2cc(ncc2cc(-c2c(Cl)c(OC)cc(OC)c2Cl)c1=O)-c1cc(NC(=O)C=C)ccc1OC

InChI Key InChIKey=UNRZERCRSJMUJU-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 103856   

TargetFibroblast growth factor receptor 4(Human)
Blueprint Medicines

US Patent
LigandPNGBDBM103856(US9695165, 39)
Affinity DataIC50: 10nMpH: 7.5 T: 2°CAssay Description:In each well of a 384-well plate, 0.5 ng/ul of wild type FGFR-4 (Carna Biosciences, Inc.) was incubated in a total of 12.5 ul of buffer (100 mM HEPES...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/26/2018
Entry Details
Go to US Patent

TargetEukaryotic translation initiation factor 2-alpha kinase 3(Human)
Blueprint Medicines

US Patent
LigandPNGBDBM103856(US9695165, 39)
Affinity DataIC50: 10nMAssay Description:MDA-MB453 cells were plated in 96-well cell culture plates at a density of 1x105 cells. Cells were allowed to attach, and growth media was replaced w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/26/2018
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 1(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM103856(US9695165, 39)
Affinity DataIC50: 1.95E+3nMAssay Description:Inhibition of wild type FGFR1 (unknown origin) using Poly (Glu,Tyr) 4:1 as substrate incubated for 60 mins in presence of ATP by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetFibroblast growth factor receptor 4(Human)
Blueprint Medicines

US Patent
LigandPNGBDBM103856(US9695165, 39)
Affinity DataIC50: 12nMAssay Description:Inhibition of FGFR4 (unknown origin) using Poly (Glu,Tyr) 4:1 as substrate incubated for 60 mins in presence of ATP by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed