BDBM104564 US8575201, 55

SMILES Nc1ncc(cn1)-c1ccc(cn1)C1(CCC1)c1noc(n1)-c1cnn(c1)C1COC1

InChI Key InChIKey=SJUWQTQEQVEDFC-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 104564   

TargetArachidonate 5-lipoxygenase-activating protein(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM104564(US8575201, 55)
Affinity DataIC50: 13nMAssay Description:Compounds area assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2014
Entry Details
Go to US Patent

TargetArachidonate 5-lipoxygenase-activating protein(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM104564(US8575201, 55)
Affinity DataIC50: 71nMAssay Description:Inhibition of FLAP in calcimycin-stimulated human whole blood assessed as reduction in LTB4 production pretreated for 15 mins followed by calcimycin ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2020
Entry Details Article
PubMed
TargetArachidonate 5-lipoxygenase-activating protein(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM104564(US8575201, 55)
Affinity DataIC50: 13nMAssay Description:Displacement of [125I]-L-691831 from human FLAP expressed in Sf9 cell membranes after 2 hrs by Topcount methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2020
Entry Details Article
PubMed