BDBM107679 1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(3-(methyl (2-methyl-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl) amino)phenyl)urea (Compound 7)

SMILES CN(c1cccc(NC(=O)Nc2ccc(Cl)c(c2)C(F)(F)F)c1)c1cc(nc(C)n1)N1CCN(C)CC1

InChI Key InChIKey=GGLLNLSQMVWDML-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 107679   

TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Shanghai Institute of Pharmaceutical Industry

LigandPNGBDBM107679(1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(3-(methy...)
Affinity DataIC50: 4.99E+3nMpH: 7.5 T: 2°CAssay Description:Compounds were prepared in DMSO at 10mmol/L and serially diluted in a 96-well plate as the source plate. The intermediate plate consists of 4µL...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/17/2014
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Shanghai Institute of Pharmaceutical Industry

LigandPNGBDBM107679(1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(3-(methy...)
Affinity DataIC50: 5.28E+3nMpH: 7.5 T: 2°CAssay Description:Compounds were prepared in DMSO at 10mmol/L and serially diluted in a 96-well plate as the source plate. The intermediate plate consists of 4µL...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/17/2014
Entry Details Article
PubMed