BDBM108442 US8609688, 20

SMILES Nc1ncccc1-c1nc2ccc(Nc3ccc(cc3)N3CCOCC3)nc2n1-c1ccc(cc1)C1(N)CCC1

InChI Key InChIKey=FHTMZOQTQFTMNQ-UHFFFAOYSA-N

Data  2 IC50  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 108442   

TargetRAC-alpha serine/threonine-protein kinase(Human)
Arqule

US Patent
LigandPNGBDBM108442(US8609688, 20)
Affinity DataKd:  57.3nMpH: 7.5 T: 2°CAssay Description:AKT1 activity was assayed using the GSK3-derived biotinylated peptide substrate, crosstide (biotin-GRPRTSSFAEG), and AlphaScreen™ (Amplified Lum...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/12/2014
Entry Details
Go to US Patent

TargetRAC-alpha serine/threonine-protein kinase(Human)
Arqule

US Patent
LigandPNGBDBM108442(US8609688, 20)
Affinity DataIC50: 8.72nMpH: 8.0 T: 2°CAssay Description:AKT1 activity was assayed using the GSK3-derived biotinylated peptide substrate, crosstide (biotin-GRPRTSSFAEG), and AlphaScreen™ (Amplified Lum...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/12/2014
Entry Details
Go to US Patent

TargetRAC-alpha serine/threonine-protein kinase(Human)
Arqule

US Patent
LigandPNGBDBM108442(US8609688, 20)
Affinity DataKd:  57.3nMAssay Description:Binding analysis. Protein-ligand binding was identified with the thermal shift assay which is based on the ligand-induced stabilization of the protei...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/15/2015
Entry Details
Go to US Patent

TargetRAC-alpha serine/threonine-protein kinase(Human)
Arqule

US Patent
LigandPNGBDBM108442(US8609688, 20)
Affinity DataIC50: 8.72nMAssay Description:AKT1 activity was assayed using the GSK3-derived biotinylated peptide substrate, crosstide (biotin-GRPRTSSFAEG), and AlphaScreen (Amplified Luminesce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/15/2015
Entry Details
Go to US Patent