BDBM10984 (3aS,8aR)-1,3a,8-trimethyl-1H,2H,3H,3aH,8H,8aH-pyrrolo[2,3-b]indol-5-yl N,N-dimethylcarbamate::CHEMBL308043::N-methylphysostigmine::Physostigmine analog 33

SMILES [H][C@]12N(C)CC[C@@]1(C)c1cc(OC(=O)N(C)C)ccc1N2C

InChI Key InChIKey=IUHMWLMDASQDJQ-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 10984   

TargetAcetylcholinesterase(Human)
National Institutes of Health

LigandPNGBDBM10984(CHEMBL308043 | N-methylphysostigmine | (3aS,8aR)-1...)
Affinity DataIC50: 210nMAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. The absorbance changes at 412 nm were recorded for 5 min with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/12/2006
Entry Details Article
PubMed
TargetCholinesterase(Human)
National Institutes of Health

LigandPNGBDBM10984(CHEMBL308043 | N-methylphysostigmine | (3aS,8aR)-1...)
Affinity DataIC50: 420nMAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. The absorbance changes at 412 nm were recorded for 5 min with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/12/2006
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
National Institutes of Health

LigandPNGBDBM10984(CHEMBL308043 | N-methylphysostigmine | (3aS,8aR)-1...)
Affinity DataIC50: 210nMAssay Description:Inhibitory activity against Acetylcholinesterase in erythrocyteMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAcetylcholinesterase(Electric eel)
Niddk

Curated by ChEMBL
LigandPNGBDBM10984(CHEMBL308043 | N-methylphysostigmine | (3aS,8aR)-1...)
Affinity DataIC50: 970nMAssay Description:Inhibitory activity against Acetylcholinesterase in electric eelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCholinesterase(Human)
National Institutes of Health

LigandPNGBDBM10984(CHEMBL308043 | N-methylphysostigmine | (3aS,8aR)-1...)
Affinity DataIC50: 420nMAssay Description:Inhibitory activity against Butyrylcholinesterase in cortexMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
National Institutes of Health

LigandPNGBDBM10984(CHEMBL308043 | N-methylphysostigmine | (3aS,8aR)-1...)
Affinity DataIC50: 970nMAssay Description:Inhibitory activity against AcetylcholinesteraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2012
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
National Institutes of Health

LigandPNGBDBM10984(CHEMBL308043 | N-methylphysostigmine | (3aS,8aR)-1...)
Affinity DataIC50: 971nMAssay Description:Inhibition acetylcholinesterase (AChE) enzyme.More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
National Institutes of Health

LigandPNGBDBM10984(CHEMBL308043 | N-methylphysostigmine | (3aS,8aR)-1...)
Affinity DataIC50: 310nMAssay Description:Inhibitory activity against Acetylcholinesterase in cortexMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCholinesterase(Human)
National Institutes of Health

LigandPNGBDBM10984(CHEMBL308043 | N-methylphysostigmine | (3aS,8aR)-1...)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibitory activity against Butyrylcholinesterase in cortexMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed