BDBM11164 (3R)-3-amino-4-(2,5-difluorophenyl)-1-[3-(2,2,2-trifluoroethyl)-5H,6H,7H,8H-[1,2,4]triazolo[3,4-a]pyrazin-7-yl]butan-1-one hydrochloride::7-[(3R)-3-Amino-4-(2,5-difluorophenyl)butanoyl]-3-(2,2,2-trifluoroethyl)-5,6,7,8-tetrahydro-1,2,4-triazolo[4,3-a]pyrazine::Triazolopiperazine Analogue 28

SMILES N[C@@H](CC(=O)N1CCn2c(CC(F)(F)F)nnc2C1)Cc1cc(F)ccc1F

InChI Key InChIKey=BWCPOKQHENWHOY-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 11164   

TargetDipeptidyl peptidase 4(Human)
Merck Research Laboratories

LigandPNGBDBM11164(7-[(3R)-3-Amino-4-(2,5-difluorophenyl)butanoyl]-3-...)
Affinity DataIC50: 103nMpH: 7.5 T: 2°CAssay Description:The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/17/2006
Entry Details Article
PubMed
TargetDipeptidyl peptidase 8(Human)
Merck Research Laboratories

LigandPNGBDBM11164(7-[(3R)-3-Amino-4-(2,5-difluorophenyl)butanoyl]-3-...)
Affinity DataIC50: 3.50E+4nMpH: 7.5 T: 2°CAssay Description:The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/17/2006
Entry Details Article
PubMed
TargetDipeptidyl peptidase 9(Human)
Merck Research Laboratories

LigandPNGBDBM11164(7-[(3R)-3-Amino-4-(2,5-difluorophenyl)butanoyl]-3-...)
Affinity DataIC50: 1.00E+5nMpH: 7.5 T: 2°CAssay Description:The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/17/2006
Entry Details Article
PubMed
TargetDipeptidyl peptidase 2(Human)
Merck Research Laboratories

LigandPNGBDBM11164(7-[(3R)-3-Amino-4-(2,5-difluorophenyl)butanoyl]-3-...)
Affinity DataIC50: 1.00E+5nMAssay Description:The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/17/2006
Entry Details Article
PubMed