BDBM111801 US10556908, Example 79::US9695180, 79

SMILES CN1CCC[C@@H](COc2nc(-c3ccc(cc3)C#N)c(-c3cc4C(O)CCc4c(F)c3)n3ccnc23)C1

InChI Key InChIKey=DFEMNDWHKPLZHB-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 111801   

LigandPNGBDBM111801(US9695180, 79 | US10556908, Example 79)
Affinity DataIC50: 50nMpH: 7.5 T: 2°CAssay Description:10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 mM NaCl, 5 mM DTT) were preincubated ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/26/2018
Entry Details
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TargetLysine-specific histone demethylase 1A(Human)
Incyte

US Patent
LigandPNGBDBM111801(US9695180, 79 | US10556908, Example 79)
Affinity DataIC50: 50nMAssay Description:LANCE LSD1/KDM1A demethylase assay 10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2020
Entry Details
Go to US Patent