BDBM111818 (2E,6E)‐2,6‐bis(2‐phenylpropylidene)cyclohexan‐1‐ one (4)

SMILES CC(C=C1CCCC(=CC(C)c2ccccc2)C1=O)c1ccccc1

InChI Key InChIKey=WLLDKGHKJACMCA-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 111818   

TargetPhospholipase A2(Human)
Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300, Kuala Lumpur, Malaysia

LigandPNGBDBM111818((2E,6E)‐2,6‐bis(2‐phenylpropylid...)
Affinity DataIC50: 9.47E+4nMpH: 8.0 T: 2°CAssay Description:Substrate 1,2-bis(heptanoylthio)-glycerophosphocholine and human recombinant PLA2-V were resuspended in assay buffer, and DTNB was dissolved in an aq...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2014
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Sheep)
Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300, Kuala Lumpur, Malaysia

LigandPNGBDBM111818((2E,6E)‐2,6‐bis(2‐phenylpropylid...)
Affinity DataIC50: 1.94E+5nMpH: 8.0 T: 2°CAssay Description:Reaction mixture containing 100 mM Tris-HCl buffer (pH 8) and COX-1 (ovine) or COX-2 (human recombinant) was preincubated for 10 min in a water bath ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2014
Entry Details Article
PubMed
TargetProstaglandin E synthase(Human)
Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300, Kuala Lumpur, Malaysia

LigandPNGBDBM111818((2E,6E)‐2,6‐bis(2‐phenylpropylid...)
Affinity DataIC50: 2.03E+4nMpH: 7.0 T: 2°CAssay Description:The assay buffer contained 100 mM KHPO4 (pH 7.0), 2 mM EDTA and 2.5 mM reduced GSH. 100 µL of reaction buffer containing human recombinant mPGES...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/18/2014
Entry Details Article
PubMed