BDBM111939 US8618107, 105

SMILES CC1(Cc2c3c(sc2C1)C(=O)N(CC3)c4cccc(c4CO)C5=CN(C(=O)C(=C5)Nc6ccncn6)C)C

InChI Key InChIKey=QAESSIFTPVEYRY-UHFFFAOYSA-N

Data  1 KI  4 IC50  2 EC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 111939   

TargetTyrosine-protein kinase BTK(Human)
Gilead Connecticut

US Patent
LigandPNGBDBM111939(US8618107, 105)
Affinity DataIC50: 10nMpH: 7.5Assay Description:A generalized procedure for a standard biochemical Btk Kinase Assay that can be used to test Formula I compounds. Alternatively, the Lanthascreen ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2014
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetTyrosine-protein kinase BTK(Human)
Gilead Connecticut

US Patent
LigandPNGBDBM111939(US8618107, 105)
Affinity DataIC50: 2nMAssay Description:Inhibition of BTK in goat anti-human IgM F(ab')2-stimulated human whole blood assessed as suppression of BCR-induced CD69 expression on B cells prein...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein kinase BTK(Mouse)
Genentech

Curated by ChEMBL
LigandPNGBDBM111939(US8618107, 105)
Affinity DataIC50: 64nMAssay Description:Inhibition of BTK in goat F(ab')2anti-mouse IgM-stimulated Balb/c mouse splenocyte B cells assessed as suppression of BCR-mediated CD86 induction pre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein kinase BTK(Human)
Gilead Connecticut

US Patent
LigandPNGBDBM111939(US8618107, 105)
Affinity DataEC50:  33nMAssay Description:Inhibition of BTK in human monocytes assessed as inhibition of FCgammaR activation-induced TNFalpha production by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein kinase BTK(Human)
Gilead Connecticut

US Patent
LigandPNGBDBM111939(US8618107, 105)
Affinity DataEC50:  22nMAssay Description:Inhibition of BTK in human B-cells assessed as decrease in BCR-stimulated B-cell proliferation after 8 hrs by [3H]-thymidine incorporation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein kinase BTK(Human)
Gilead Connecticut

US Patent
LigandPNGBDBM111939(US8618107, 105)
Affinity DataIC50: 87nMAssay Description:Inhibition of BTK in goat anti-human IgM F(ab')2-stimulated human whole blood assessed as suppression of BCR-induced CD69 expression on B cells prein...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein kinase BTK(Human)
Gilead Connecticut

US Patent
LigandPNGBDBM111939(US8618107, 105)
Affinity DataKi:  1.30nMAssay Description:Inhibition of recombinant human full length His-tagged BTK expressed in baculovirus expression system by Z-LYTE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)