BDBM1128 (4R,5R,6R)-1-[(3-aminophenyl)methyl]-6-benzyl-5-hydroxy-4-(2-phenylethyl)-1,3-diazinan-2-one::(4R,5R,6R)-Tetrahydro-1-(3-aminophenylmethyl)-6-phenylmethyl-5-hydroxy-4-(2-phenylethyl)-2(1H)-pyrimidinone::Tetrahydropyrimidinone deriv. 47

SMILES Nc1cccc(CN2[C@H](Cc3ccccc3)[C@H](O)[C@@H](CCc3ccccc3)NC2=O)c1

InChI Key InChIKey=JZUOZVFRPLKQLG-UHFFFAOYSA-N

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 1128   

TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Dupont Pharmaceuticals

LigandPNGBDBM1128((4R,5R,6R)-1-[(3-aminophenyl)methyl]-6-benzyl-5-hy...)
Affinity DataKi:  6.20nMAssay Description:Inhibition of HIV protease was measured by assay of the cleavage of a fluorescent peptide substrate. The fluorescent product (2-aminobenzoyl-Ala-Thr-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2004
Entry Details Article
PubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
University of Florida

Curated by ChEMBL
LigandPNGBDBM1128((4R,5R,6R)-1-[(3-aminophenyl)methyl]-6-benzyl-5-hy...)
Affinity DataKi:  6.20nMAssay Description:Inhibitory activity of compound against HIV-1 aspartyl protease.More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
University of Florida

Curated by ChEMBL
LigandPNGBDBM1128((4R,5R,6R)-1-[(3-aminophenyl)methyl]-6-benzyl-5-hy...)
Affinity DataKi:  6.20nMAssay Description:Inhibition of HIV protease was measured by assay of the cleavage of a fluorescent peptide substrate. The fluorescent product (2-aminobenzoyl-Ala-Thr-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2004
Entry Details Article
PubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
University of Florida

Curated by ChEMBL
LigandPNGBDBM1128((4R,5R,6R)-1-[(3-aminophenyl)methyl]-6-benzyl-5-hy...)
Affinity DataKi:  158nMAssay Description:Inhibitory activity against HIV-1 proteaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed