BDBM113210 US8633206, 129

SMILES C[C@@H]1C[C@@H](CS(=O)(=O)N2CCC[C@@H](O)C2)CC[C@@H]1N(C)c1ncnc2[nH]ccc12

InChI Key InChIKey=RRWIERVKMPBTBE-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 113210   

TargetTyrosine-protein kinase JAK1(Human)
Pfizer

US Patent
LigandPNGBDBM113210(US8633206, 129)
Affinity DataIC50: 1.70nMpH: 7.4Assay Description:A peptide mobility shift assay was used to quantify the phosphorylation of the JAKtide (JAK2 and JAK3) or the IRS-1 peptide (JAK1 and Tyk2). Reaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2014
Entry Details
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TargetTyrosine-protein kinase JAK3(Human)
Pfizer

US Patent
LigandPNGBDBM113210(US8633206, 129)
Affinity DataIC50: 19.4nMpH: 7.4Assay Description:A peptide mobility shift assay was used to quantify the phosphorylation of the JAKtide (JAK2 and JAK3) or the IRS-1 peptide (JAK1 and Tyk2). Reaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2014
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK2(Human)
Pfizer

US Patent
LigandPNGBDBM113210(US8633206, 129)
Affinity DataIC50: 6.89nMpH: 7.4Assay Description:A peptide mobility shift assay was used to quantify the phosphorylation of the JAKtide (JAK2 and JAK3) or the IRS-1 peptide (JAK1 and Tyk2). Reaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2014
Entry Details
Go to US Patent