BDBM11328 CHEMBL83508::Hydroxamate 9::N-hydroxy-2-[(4-methoxybenzene)sulfonamido]acetamide

SMILES COc1ccc(cc1)S(=O)(=O)NCC(=O)NO

InChI Key InChIKey=WLZISXXOYYGJNT-UHFFFAOYSA-N

Data  14 KI  6 IC50

PDB links: 2 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 20 hits for monomerid = 11328   

TargetMatrix metalloproteinase-14(Human)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM11328(CHEMBL83508 | N-hydroxy-2-[(4-methoxybenzene)sulfo...)
Affinity DataIC50: 210nMAssay Description:Inhibition of human recombinant MMP14 by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetMeprin A subunit beta(Human)
Fraunhofer Institute For Cell Therapy and Immunology Izi

Curated by ChEMBL
LigandPNGBDBM11328(CHEMBL83508 | N-hydroxy-2-[(4-methoxybenzene)sulfo...)
Affinity DataIC50: 9.02E+3nMAssay Description:Inhibition of recombinant human meprin beta expressed in yeast using Abz-YVAEAPK(Dnp)G-OH as substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2019
Entry Details Article
PubMed
LigandPNGBDBM11328(CHEMBL83508 | N-hydroxy-2-[(4-methoxybenzene)sulfo...)
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of human recombinant ADAM17 by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM11328(CHEMBL83508 | N-hydroxy-2-[(4-methoxybenzene)sulfo...)
Affinity DataIC50: 32nMAssay Description:Inhibition of MMP2 by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM11328(CHEMBL83508 | N-hydroxy-2-[(4-methoxybenzene)sulfo...)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of MMP1 by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM11328(CHEMBL83508 | N-hydroxy-2-[(4-methoxybenzene)sulfo...)
Affinity DataIC50: 130nMAssay Description:Inhibition of MMP9 by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetMacrophage metalloelastase(Human)
University of Florence

Curated by ChEMBL
LigandPNGBDBM11328(CHEMBL83508 | N-hydroxy-2-[(4-methoxybenzene)sulfo...)
Affinity DataKi:  20nMAssay Description:Inhibition of MMP12 (unknown origin)-mediated Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCarbonic anhydrase 4(Bovine)
Universita Degli Studi

LigandPNGBDBM11328(CHEMBL83508 | N-hydroxy-2-[(4-methoxybenzene)sulfo...)
Affinity DataKi:  29nMAssay Description:Initial rates of 4-nitrophenyl acetate hydrolysis catalyzed by different CA isozymes were monitored spectrophotometrically at 400 nm. A molar absorpt...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2006
Entry Details Article
PubMed
TargetCarbonic anhydrase 1(Human)
Universita Degli Studi

LigandPNGBDBM11328(CHEMBL83508 | N-hydroxy-2-[(4-methoxybenzene)sulfo...)
Affinity DataKi:  30nM ΔG°:  -10.3kcal/molepH: 7.4 T: 2°CAssay Description:Initial rates of 4-nitrophenyl acetate hydrolysis catalyzed by different CA isozymes were monitored spectrophotometrically at 400 nm. A molar absorpt...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2006
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
Universita Degli Studi

LigandPNGBDBM11328(CHEMBL83508 | N-hydroxy-2-[(4-methoxybenzene)sulfo...)
Affinity DataKi:  32nMAssay Description:Initial rates of 4-nitrophenyl acetate hydrolysis catalyzed by different CA isozymes were monitored spectrophotometrically at 400 nm. A molar absorpt...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2006
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM11328(CHEMBL83508 | N-hydroxy-2-[(4-methoxybenzene)sulfo...)
Affinity DataKi:  33nMAssay Description:Binding affinity towards (MMP-1) matrix metalloprotease-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM11328(CHEMBL83508 | N-hydroxy-2-[(4-methoxybenzene)sulfo...)
Affinity DataKi:  110nMAssay Description:Initial rates of 4-nitrophenyl acetate hydrolysis catalyzed by different CA isozymes were monitored spectrophotometrically at 400 nm. A molar absorpt...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2006
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM11328(CHEMBL83508 | N-hydroxy-2-[(4-methoxybenzene)sulfo...)
Affinity DataKi:  110nMAssay Description:Inhibition of MMP2More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2013
Entry Details Article
PubMed
TargetCollagenase ColG(Hathewaya histolytica)
Universita Degli Studi

LigandPNGBDBM11328(CHEMBL83508 | N-hydroxy-2-[(4-methoxybenzene)sulfo...)
Affinity DataKi:  120nMAssay Description:Initial rates of 4-nitrophenyl acetate hydrolysis catalyzed by different CA isozymes were monitored spectrophotometrically at 400 nm. A molar absorpt...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2006
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM11328(CHEMBL83508 | N-hydroxy-2-[(4-methoxybenzene)sulfo...)
Affinity DataKi:  143nMAssay Description:Initial rates of 4-nitrophenyl acetate hydrolysis catalyzed by different CA isozymes were monitored spectrophotometrically at 400 nm. A molar absorpt...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2006
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM11328(CHEMBL83508 | N-hydroxy-2-[(4-methoxybenzene)sulfo...)
Affinity DataKi:  145nMAssay Description:Inhibition of MMP9More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2013
Entry Details Article
PubMed
TargetNeutrophil collagenase(Human)
Universita Degli Studi

LigandPNGBDBM11328(CHEMBL83508 | N-hydroxy-2-[(4-methoxybenzene)sulfo...)
Affinity DataKi:  155nMAssay Description:Initial rates of 4-nitrophenyl acetate hydrolysis catalyzed by different CA isozymes were monitored spectrophotometrically at 400 nm. A molar absorpt...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2006
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM11328(CHEMBL83508 | N-hydroxy-2-[(4-methoxybenzene)sulfo...)
Affinity DataKi: >200nMAssay Description:Initial rates of 4-nitrophenyl acetate hydrolysis catalyzed by different CA isozymes were monitored spectrophotometrically at 400 nm. A molar absorpt...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2006
Entry Details Article
PubMed
TargetMatrilysin(Human)
University of Florence

Curated by ChEMBL
LigandPNGBDBM11328(CHEMBL83508 | N-hydroxy-2-[(4-methoxybenzene)sulfo...)
Affinity DataKi:  4.00E+3nMAssay Description:Inhibition of MMP7 (unknown origin)-mediated Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Novartis Pharmaceuticals

LigandPNGBDBM11328(CHEMBL83508 | N-hydroxy-2-[(4-methoxybenzene)sulfo...)
Affinity DataKi:  4.40E+3nMAssay Description:Stromelysin inhibitory activity is based on the hydrolysis of substance P by recombinant human stromelysin to generate a fragment, substance P 7-11, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/15/2007
Entry Details Article
PubMedPDB3D3D Structure (crystal)