BDBM113767 (E)-6-((1R,2R)-3,3-Dimethyl-2-(3-methylbut-3-enyl)cyclobutyl)-N-(4-hydroxy-3-methoxybenzyl)hepta-2,6-dienamide (11e)

SMILES COc1cc(CNC(=O)\C=C\CCC(=C)[C@@H]2CC(C)(C)[C@@H]2CCC(C)=C)ccc1O

InChI Key InChIKey=DZGJGFLRZPMFPG-UHFFFAOYSA-N

Data  2 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 113767   

TargetFatty-acid amide hydrolase 1(Human)
University of Bern

LigandPNGBDBM113767((E)-6-((1R,2R)-3,3-Dimethyl-2-(3-methylbut-3-enyl)...)
Affinity DataIC50: 7.10E+3nMpH: 7.6 T: 2°CAssay Description:In this assay, 0.05 Units of hFAAH was pre-incubated for 30 min at 37 C with 2 uL of 11a, 11b, 11f at different concentrations (0.01 - 100 uM) or veh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2014
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
University of Bern

LigandPNGBDBM113767((E)-6-((1R,2R)-3,3-Dimethyl-2-(3-methylbut-3-enyl)...)
Affinity DataIC50: 1.45E+4nMpH: 8.0 T: 2°CAssay Description:Tested compounds (50 uM), DuP-597 (0.5 uM; positive control), 11f and 11eie(1 nM - 200 uM ) or vehicle were pre-incubated with COX-FIS assay buffer (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2014
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
University of Bern

LigandPNGBDBM113767((E)-6-((1R,2R)-3,3-Dimethyl-2-(3-methylbut-3-enyl)...)
Affinity DataIC50: 2.20E+3nMpH: 8.0 T: 2°CAssay Description:Tested compounds (50 uM), DuP-597 (0.5 uM; positive control), 11f and 11eie(1 nM - 200 uM ) or vehicle were pre-incubated with COX-FIS assay buffer (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2014
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Human)
University of Bern

LigandPNGBDBM113767((E)-6-((1R,2R)-3,3-Dimethyl-2-(3-methylbut-3-enyl)...)
Affinity DataKi: >1.00E+4nM ΔG°: >-6.93kcal/molepH: 7.4 T: 2°CAssay Description:In this assay, 18 ug of crude membrane expressing hCB1 or hCB2 receptors were re-suspended in 300 uL of binding buffer containing 50 mM Tris-HCl, 2.5...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2014
Entry Details Article
PubMed
TargetCannabinoid receptor 2(Human)
University of Bern

LigandPNGBDBM113767((E)-6-((1R,2R)-3,3-Dimethyl-2-(3-methylbut-3-enyl)...)
Affinity DataKi: >1.00E+4nM ΔG°: >-6.93kcal/molepH: 7.4 T: 2°CAssay Description:In this assay, 18 ug of crude membrane expressing hCB1 or hCB2 receptors were re-suspended in 300 uL of binding buffer containing 50 mM Tris-HCl, 2.5...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2014
Entry Details Article
PubMed