BDBM118295 US8653092, 63

SMILES CCC(=O)N1CC[C@@H](C1)Oc1ncnc2CCN(Cc12)c1cnc(OC)c(c1)C(F)(F)F

InChI Key InChIKey=ZADGOAAFZDRNIQ-UHFFFAOYSA-N

Data  11 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 118295   

LigandPNGBDBM118295(US8653092, 63)
Affinity DataIC50: 23nMAssay Description:Inhibition of PI3Kdelta (unknown origin) using phosphatidyl inositol as substrate measured after 60 mins in presence of [33P]ATP by Scintillation pro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
LigandPNGBDBM118295(US8653092, 63)
Affinity DataIC50: 27nMAssay Description:Inhibition of PI3Kdelta (unknown origin) using phosphatidyl inositol as substrate measured after 60 mins by Alexa Fluor647-labelled ADP tracer based ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/7/2020
Entry Details Article
PubMed
LigandPNGBDBM118295(US8653092, 63)
Affinity DataIC50: 51nMAssay Description:Test of Lipid Kinase Activity: The kinase reaction is performed in a final volume of 50 μl per well of a half area COSTAR, 96 well plate. The fi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2014
Entry Details
US Patent

LigandPNGBDBM118295(US8653092, 63)
Affinity DataIC50: 131nMAssay Description:Inhibition of recombinant human myristoylated PI3Kdelta catalytic domain expressed in Rat1 cells assessed as reduction in Akt phosphorylation at Ser4...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/7/2020
Entry Details Article
PubMed
LigandPNGBDBM118295(US8653092, 63)
Affinity DataIC50: 262nMAssay Description:Inhibition of PI3Kalpha (unknown origin) using phosphatidyl inositol as substrate measured after 60 mins in presence of [33P]ATP by Scintillation pro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
LigandPNGBDBM118295(US8653092, 63)
Affinity DataIC50: 791nMAssay Description:Test of Lipid Kinase Activity: The kinase reaction is performed in a final volume of 50 μl per well of a half area COSTAR, 96 well plate. The fi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2014
Entry Details
US Patent

LigandPNGBDBM118295(US8653092, 63)
Affinity DataIC50: 792nMAssay Description:Inhibition of recombinant PI3Kalpha (unknown origin) using phosphatidyl inositol/n-Octyl-glucoside as substrate measured after 30 mins by KinaseGlo a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/7/2020
Entry Details Article
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM118295(US8653092, 63)
Affinity DataIC50: 1.71E+3nMAssay Description:Inhibition of recombinant PI3Kbeta (unknown origin) using phosphatidyl inositol/n-Octyl-glucoside as substrate measured after 60 mins by KinaseGlo as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/7/2020
Entry Details Article
PubMed
LigandPNGBDBM118295(US8653092, 63)
Affinity DataIC50: 2.60E+3nMAssay Description:Inhibition of recombinant human myristoylated PI3Kalpha catalytic domain expressed in Rat1 cells assessed as reduction in Akt phosphorylation at Ser4...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/7/2020
Entry Details Article
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM118295(US8653092, 63)
Affinity DataIC50: 3.11E+3nMAssay Description:Inhibition of recombinant human myristoylated PI3Kbeta catalytic domain expressed in Rat1 cells assessed as reduction in Akt phosphorylation at Ser47...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/7/2020
Entry Details Article
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM118295(US8653092, 63)
Affinity DataIC50: 9.10E+3nMAssay Description:Inhibition of PI3Kgamma (unknown origin) using phosphatidyl inositol as substrate measured after 30 mins by Alexa Fluor647-labelled ADP tracer based ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/7/2020
Entry Details Article
PubMed