BDBM12232 AZD0530 analogue 10::CHEMBL381206::N-(2-chloro-5-methoxyphenyl)-7-[3-(morpholin-4-yl)propoxy]-5-(propan-2-yloxy)quinazolin-4-amine

SMILES COc1ccc(Cl)c(Nc2ncnc3cc(OCCCN4CCOCC4)cc(OC(C)C)c23)c1

InChI Key InChIKey=BTKHYUXUOJGROG-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 12232   

TargetVascular endothelial growth factor receptor 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM12232(N-(2-chloro-5-methoxyphenyl)-7-[3-(morpholin-4-yl)...)
Affinity DataIC50: 30nMAssay Description:Inhibitory activity against KDRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM12232(N-(2-chloro-5-methoxyphenyl)-7-[3-(morpholin-4-yl)...)
Affinity DataIC50: 30nMAssay Description:This assay determines the ability of test compounds to inhibit Src kinase activity that catalyzes the transfer of the terminal phosphate to the immob...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2006
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM12232(N-(2-chloro-5-methoxyphenyl)-7-[3-(morpholin-4-yl)...)
Affinity DataIC50: 40nMAssay Description:Inhibitory activity against c-Src kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM12232(N-(2-chloro-5-methoxyphenyl)-7-[3-(morpholin-4-yl)...)
Affinity DataIC50: 40nMpH: 7.4 T: 2°CAssay Description:This assay determines the ability of test compounds to inhibit Src kinase activity that catalyzes the transfer of the terminal phosphate to the immob...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2006
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM12232(N-(2-chloro-5-methoxyphenyl)-7-[3-(morpholin-4-yl)...)
Affinity DataIC50: 150nMAssay Description:Inhibition of Src-transfected 3T3 cell proliferationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed