BDBM123410 US8741926, 82::US8754106, 82::US8754106, 91

SMILES COc1ccc2c(O[C@H]3C[C@@H]4[C@@H](C3)C(=O)N[C@@]3(C[C@H]3\C=C/CCCCCNC4=O)C(=O)NS(=O)(=O)C3CC3)cc(nc2c1C)-c1nc(cs1)C(C)C

InChI Key InChIKey=ZIHXHTFVLKLWNX-UHFFFAOYSA-N

Data  3 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 123410   

TargetGenome polyprotein(Hepacivirus C)
Janssen Ireland

US Patent
LigandPNGBDBM123410(US8754106, 82 | US8754106, 91 | US8741926, 82)
Affinity DataKi:  0.0500nMAssay Description:The aim of this in vitro assay was to measure the inhibition of HCV NS3/4A protease complexes by the compounds of the present invention. This assay p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2014
Entry Details
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TargetGenome polyprotein(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Janssen Ireland

US Patent
LigandPNGBDBM123410(US8754106, 82 | US8754106, 91 | US8741926, 82)
Affinity DataKi:  9.40nM ΔG°:  -11.1kcal/molepH: 7.5 T: 2°CAssay Description:The inhibition of full-length hepatitis C NS3 protease enzyme was measured essentially as described in Poliakov, 2002 Prot Expression & Purification ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/5/2014
Entry Details
Go to US Patent

TargetGenome polyprotein(Hepacivirus C)
Janssen Ireland

US Patent
LigandPNGBDBM123410(US8754106, 82 | US8754106, 91 | US8741926, 82)
Affinity DataKi:  9.40nMAssay Description:The aim of this in vitro assay was to measure the inhibition of HCV NS3/4A protease complexes by the compounds of the present invention. This assay p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2014
Entry Details
Go to US Patent