BDBM123415 US8741926, 95::US8754106, 95

SMILES COc1ccc2c(O[C@@H]3C[C@@H]4N(C3)C(=O)NCCCCC\C=C/[C@@H]3C[C@]3(NC4=O)C(=O)NS(=O)(=O)C3(C)CC3)cc(nc2c1Cl)-c1nc(cs1)C(C)C

InChI Key InChIKey=IHXGLDBKRROHDN-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 123415   

TargetGenome polyprotein(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Janssen Ireland

US Patent
LigandPNGBDBM123415(US8754106, 95 | US8741926, 95)
Affinity DataKi:  0.100nM ΔG°:  -13.9kcal/molepH: 7.5 T: 2°CAssay Description:The inhibition of full-length hepatitis C NS3 protease enzyme was measured essentially as described in Poliakov, 2002 Prot Expression & Purification ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/5/2014
Entry Details
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TargetGenome polyprotein(Hepacivirus C)
Janssen Ireland

US Patent
LigandPNGBDBM123415(US8754106, 95 | US8741926, 95)
Affinity DataKi:  0.100nMAssay Description:The aim of this in vitro assay was to measure the inhibition of HCV NS3/4A protease complexes by the compounds of the present invention. This assay p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2014
Entry Details
Go to US Patent