BDBM125403 US8772480, 246

SMILES COc1ncc(Nc2ncccc2-c2nc(C)nc(N)n2)cc1F

InChI Key InChIKey=MSQQWMIPDSCJOT-UHFFFAOYSA-N

Data  1 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 125403   

TargetSerine/threonine-protein kinase mTOR(Human)
Amgen

US Patent
LigandPNGBDBM125403(US8772480, 246)
Affinity DataIC50: 1.00E+4nMAssay Description:The Invitrogen (Carlsbad, Calif.) mammalian target of rapamycin (mTOR) Lanthascreen assay can be used to quantitate mTOR kinase activity in an in vit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2014
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase mTOR(Human)
Amgen

US Patent
LigandPNGBDBM125403(US8772480, 246)
Affinity DataIC50: 2.20E+4nMAssay Description:Inhibition of recombinant N-terminally GST-tagged mTOR (1360 to 2549 aa) (unknown origin) assessed as inhibition of 27BP1 phosphorylation after 90 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/17/2016
Entry Details Article
PubMed
LigandPNGBDBM125403(US8772480, 246)
Affinity DataKi:  19nMAssay Description:The PI3K AlphaScreen assay (PerkinElmer, Waltham, Mass.) measures the activity of a panel of four phosphoinositide 3-kinases: PI3Kalpha, PI3Kbeta, PI...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2014
Entry Details
Go to US Patent