BDBM126019 US8779142, 7

SMILES CC(C)c1nn(-c2ccc(C(N)=O)c(N[C@H]3CC[C@H](O)CC3)c2)c2nccc(-c3cccnc3)c12

InChI Key InChIKey=KXRXYDBRDVRGMB-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 126019   

TargetHeat shock protein HSP 90-alpha(Human)
Taiho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM126019(US8779142, 7)
Affinity DataIC50: 166nMAssay Description:Displacement of biotin-labeled geldanamycin from His-tagged HSP90alpha NTD (unknown origin) preincubated for 2 hrs followed by biotin-labeled geldana...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-alpha(Human)
Taiho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM126019(US8779142, 7)
Affinity DataIC50: 340nMpH: 7.5Assay Description:The HSP90-binding activity was measured by an AlphaScreen competitive assay system. The purified HSP90 solution was diluted with a binding buffer (50...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2014
Entry Details
US Patent