BDBM128081 US8796330, 145

SMILES ONC(=O)\C=C\c1ccc(NC(=O)Nc2ccc(Cl)cc2)cc1

InChI Key InChIKey=BPQUKDOJAFTDQI-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 128081   

TargetHistone deacetylase 1(Human)
Methylgene

US Patent
LigandPNGBDBM128081(US8796330, 145)
Affinity DataIC50: 840nMT: 2°CAssay Description:For deacetylase assays, 20,000 cpm of the [3H]-metabolically labeled acetylated histone substrate (M. Yoshida et al., J. Biol. Chem. 265(28): 17174-1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2014
Entry Details
Go to US Patent

TargetHistone deacetylase 8(Human)TBA
LigandPNGBDBM128081(US8796330, 145)
Affinity DataIC50: 840nMAssay Description:Inhibition of Homo sapiens (human) HDAC8More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article

TargetHistone deacetylase 1(Human)
Methylgene

US Patent
LigandPNGBDBM128081(US8796330, 145)
Affinity DataIC50: 3.26E+3nMAssay Description:Inhibition of recombinant human full-length C-terminal FLAG/His-tagged HDAC1 (1 to 482 residues) expressed in baculovirus infected Sf9 insect cells u...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
University of S£O Paulo

Curated by ChEMBL
LigandPNGBDBM128081(US8796330, 145)
Affinity DataIC50: 8.10nMAssay Description:Inhibition of recombinant human full-length N-terminal GST-tagged HDAC6 (1 to 1215 residues) expressed in baculovirus infected Sf9 insect cells using...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed