BDBM12984 4-(4-methylpiperazin-1-yl)-N-{5-[(2R)-2-phenylpropanoyl]-1H,4H,5H,6H-pyrrolo[3,4-c]pyrazol-3-yl}benzamide::5-Amido-pyrrolopyrazole 9c::CHEMBL427787

SMILES C[C@@H](C(=O)N1Cc2n[nH]c(NC(=O)c3ccc(cc3)N3CCN(C)CC3)c2C1)c1ccccc1

InChI Key InChIKey=CAQRLZFEWBTCCO-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 12984   

TargetAurora kinase A(Human)
Nerviano Medical Sciences

LigandPNGBDBM12984(CHEMBL427787 | 4-(4-methylpiperazin-1-yl)-N-{5-[(2...)
Affinity DataIC50: 24nMpH: 7.5 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates in the presence ATP/[gamma-33P] ATP. After in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/9/2007
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Nerviano Medical Sciences

LigandPNGBDBM12984(CHEMBL427787 | 4-(4-methylpiperazin-1-yl)-N-{5-[(2...)
Affinity DataIC50: 99nMpH: 7.5 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates in the presence ATP/[gamma-33P] ATP. After in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/9/2007
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Nerviano Medical Sciences

LigandPNGBDBM12984(CHEMBL427787 | 4-(4-methylpiperazin-1-yl)-N-{5-[(2...)
Affinity DataIC50: 99nMAssay Description:Inhibition of aurora B kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2012
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Nerviano Medical Sciences

LigandPNGBDBM12984(CHEMBL427787 | 4-(4-methylpiperazin-1-yl)-N-{5-[(2...)
Affinity DataIC50: 24nMAssay Description:Inhibition of aurora A kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2012
Entry Details Article
PubMed