BDBM12987 5-Amido-pyrrolopyrazole 9f::CHEMBL384575::N-{5-[(2S)-2-methoxy-2-phenylacetyl]-1H,4H,5H,6H-pyrrolo[3,4-c]pyrazol-3-yl}-4-(4-methylpiperazin-1-yl)benzamide

SMILES CO[C@H](C(=O)N1Cc2n[nH]c(NC(=O)c3ccc(cc3)N3CCN(C)CC3)c2C1)c1ccccc1

InChI Key InChIKey=XKFTZKGMDDZMJI-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 12987   

TargetAurora kinase A(Human)
Nerviano Medical Sciences

LigandPNGBDBM12987(CHEMBL384575 | N-{5-[(2S)-2-methoxy-2-phenylacetyl...)
Affinity DataIC50: 354nMpH: 7.5 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates in the presence ATP/[gamma-33P] ATP. After in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/9/2007
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Nerviano Medical Sciences

LigandPNGBDBM12987(CHEMBL384575 | N-{5-[(2S)-2-methoxy-2-phenylacetyl...)
Affinity DataIC50: 630nMpH: 7.5 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates in the presence ATP/[gamma-33P] ATP. After in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/9/2007
Entry Details Article
PubMed
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Human)
The First People'S Hospital of Hangzhou

Curated by ChEMBL
LigandPNGBDBM12987(CHEMBL384575 | N-{5-[(2S)-2-methoxy-2-phenylacetyl...)
Affinity DataIC50: 25nMAssay Description:Inhibition of BCR-ABL kinase (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2014
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Nerviano Medical Sciences

LigandPNGBDBM12987(CHEMBL384575 | N-{5-[(2S)-2-methoxy-2-phenylacetyl...)
Affinity DataIC50: 630nMAssay Description:Inhibition of aurora B kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2012
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Nerviano Medical Sciences

LigandPNGBDBM12987(CHEMBL384575 | N-{5-[(2S)-2-methoxy-2-phenylacetyl...)
Affinity DataIC50: 354nMAssay Description:Inhibition of aurora A kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2012
Entry Details Article
PubMed