BDBM129964 US8815926, 245::US8815926, 275

SMILES COc1nc(ncc1-c1nc2C(=O)N(C(c2n1C(C)C)c1ccc(Cl)cn1)c1cc(Cl)ccc1C)N(C)C

InChI Key InChIKey=LQUVMDCDNGTXTQ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 129964   

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Novartis

US Patent
LigandPNGBDBM129964(US8815926, 275 | US8815926, 245)
Affinity DataIC50: 0.120nMAssay Description:The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/26/2015
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Novartis

US Patent
LigandPNGBDBM129964(US8815926, 275 | US8815926, 245)
Affinity DataIC50: 0.122nMAssay Description:The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/26/2015
Entry Details
US Patent