BDBM13221 BMS-354825 tert-Butoxycarbamate Analog 5e::CHEMBL132448::tert-butyl N-{5-[(2,6-dichlorophenyl)carbamoyl]-4-methyl-1,3-thiazol-2-yl}carbamate

SMILES Cc1nc(NC(=O)OC(C)(C)C)sc1C(=O)Nc1c(Cl)cccc1Cl

InChI Key InChIKey=MQPQHDGTTOFMHE-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 13221   

TargetTyrosine-protein kinase Lck(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM13221(tert-butyl N-{5-[(2,6-dichlorophenyl)carbamoyl]-4-...)
Affinity DataIC50: 1.25E+4nMAssay Description:Inhibition of human Lck(hLck) kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM13221(tert-butyl N-{5-[(2,6-dichlorophenyl)carbamoyl]-4-...)
Affinity DataIC50: 1.25E+4nMpH: 7.0 T: 2°CAssay Description:IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-33P] lab...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/22/2007
Entry Details Article
PubMed