BDBM137225 US8871790, 297

SMILES CC(C)CNC(=O)Nc1cc(ccc1C)C(=O)N1CCC(F)(CC1)c1ccc(cc1)C#N

InChI Key InChIKey=AWGLLQHLDDCYEK-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 137225   

TargetFatty acid synthase(Human)
Sagimet Biosciences

US Patent
LigandPNGBDBM137225(US8871790, 297 | US20250017938, Compound 001-297)
Affinity DataIC50: 25nMAssay Description:Determination of FASN biochemical activity: The FASN enzyme was isolated from SKBr3 cells. SKBr3 is a human breast cancer cell-line with high levels ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2025
Entry Details
US Patent

TargetFatty acid synthase(Human)
Sagimet Biosciences

US Patent
LigandPNGBDBM137225(US8871790, 297 | US20250017938, Compound 001-297)
Affinity DataIC50: 25nMAssay Description:The FASN enzyme was isolated from SKBr3 cells. SKBr3 is a human breast cancer cell-line with high levels of FASN expression. It is estimated that FAS...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/6/2015
Entry Details
US Patent