BDBM140988 US8916574, Compound 5

SMILES Fc1cccc(COc2ccc(Nc3ncnc4ccc(cc34)-c3ccc(CNCCS(=O)(=O)CC(F)(F)F)o3)cc2Cl)c1

InChI Key InChIKey=VPRLBIZASKQOSZ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 140988   

TargetEpidermal growth factor receptor(Human)
Qilu Pharmaceutical

US Patent
LigandPNGBDBM140988(US8916574, Compound 5)
Affinity DataIC50: 14.6nMT: 2°CAssay Description:In vitro kinase analysis was performed by using HTScan EGF Receptor Kinase Assay Kit (#7909) and HTScan HER2/ErbB2 Kinase Assay Kit (#7058) from Cell...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/11/2015
Entry Details
Go to US Patent

TargetReceptor tyrosine-protein kinase erbB-2(Human)
Qilu Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM140988(US8916574, Compound 5)
Affinity DataIC50: 8.60nMAssay Description:Inhibition of HER-2 (unknown origin) using poly-(Glu4-Tyr) as substrate after 1 hr by ELISA-based spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Qilu Pharmaceutical

US Patent
LigandPNGBDBM140988(US8916574, Compound 5)
Affinity DataIC50: 21nMAssay Description:Inhibition of EGFR (unknown origin) using poly-(Glu4-Tyr) as substrate after 1 hr by ELISA-based spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed