BDBM140995 US10570123, Example 167::US8916576, 167

SMILES COc1cc2nc(nc(Nc3ccc4[nH]ncc4c3)c2cc1OCCN1CCCC1)-c1cccc(NC(=O)CN2CCOCC2)c1

InChI Key InChIKey=RYOMMGAHCJKUDG-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 140995   

TargetRho-associated protein kinase 2(Human)
Surface Logix

US Patent
LigandPNGBDBM140995(US8916576, 167 | US10570123, Example 167)
Affinity DataIC50: 60nMAssay Description:ROCK-II inhibitory activity can be measured using the ROCK-II Assay Kit (Molecular Devices, inc.; Sunnyvale, Calif.).More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/11/2015
Entry Details
Go to US Patent

TargetRho-associated protein kinase 1(Human)
Surface Logix

US Patent
LigandPNGBDBM140995(US8916576, 167 | US10570123, Example 167)
Affinity DataIC50: 3.00E+3nMAssay Description:ROCK-II inhibitory activity can be measured using the ROCK-II Assay Kit (Molecular Devices, inc.; Sunnyvale, Calif.).More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/11/2015
Entry Details
Go to US Patent

TargetRho-associated protein kinase 1(Human)
Surface Logix

US Patent
LigandPNGBDBM140995(US8916576, 167 | US10570123, Example 167)
Affinity DataIC50: 3.00E+3nMAssay Description:ROCK-II inhibitory activity can be measured using the ROCK-II Assay Kit (Molecular Devices, inc.; Sunnyvale, Calif.).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2020
Entry Details
Go to US Patent

TargetRho-associated protein kinase 2(Human)
Surface Logix

US Patent
LigandPNGBDBM140995(US8916576, 167 | US10570123, Example 167)
Affinity DataIC50: 60nMAssay Description:ROCK-II inhibitory activity can be measured using the ROCK-II Assay Kit (Molecular Devices, inc.; Sunnyvale, Calif.).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2020
Entry Details
Go to US Patent