BDBM141252 US8653100, 146::US8653100, 152::US8653100, 154::US8653100, 158

SMILES NCCS(=O)(=O)NCCOc1ccc2CCNC(c2c1)C1(CCC1)c1ccc(Cl)cc1

InChI Key InChIKey=JVWGCNRZGSAAFG-UHFFFAOYSA-N

Data  4 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 141252   

LigandPNGBDBM141252(US8653100, 152 | US8653100, 154 | US8653100, 158 |...)
Affinity DataKi: <100nMpH: 7.5Assay Description:Radioligand binding to human GlyT1c transporter-expressing membranes was carried out as described in Mezler et al., Molecular Pharmacology 74:1705-17...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/18/2015
Entry Details
US Patent

LigandPNGBDBM141252(US8653100, 152 | US8653100, 154 | US8653100, 158 |...)
Affinity DataKi: <100nMpH: 7.5Assay Description:Radioligand binding to human GlyT1c transporter-expressing membranes was carried out as described in Mezler et al., Molecular Pharmacology 74:1705-17...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/18/2015
Entry Details
US Patent

LigandPNGBDBM141252(US8653100, 152 | US8653100, 154 | US8653100, 158 |...)
Affinity DataKi: <100nMpH: 7.5Assay Description:Radioligand binding to human GlyT1c transporter-expressing membranes was carried out as described in Mezler et al., Molecular Pharmacology 74:1705-17...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/18/2015
Entry Details
US Patent

LigandPNGBDBM141252(US8653100, 152 | US8653100, 154 | US8653100, 158 |...)
Affinity DataKi: <100nMpH: 7.5Assay Description:Radioligand binding to human GlyT1c transporter-expressing membranes was carried out as described in Mezler et al., Molecular Pharmacology 74:1705-17...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/18/2015
Entry Details
US Patent

LigandPNGBDBM141252(US8653100, 152 | US8653100, 154 | US8653100, 158 |...)
Affinity DataIC50: 1.00E+3nMAssay Description:[3H]-Glycine uptake into recombinant CHO cells expressing human GlyT1: Human GlyT1c expressing recombinant hGlyT1c_5_CHO cells were plated at 20,000 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/18/2015
Entry Details
US Patent

LigandPNGBDBM141252(US8653100, 152 | US8653100, 154 | US8653100, 158 |...)
Affinity DataIC50: 1.00E+4nMAssay Description:[3H]-Glycine uptake into recombinant CHO cells expressing human GlyT1: Human GlyT1c expressing recombinant hGlyT1c_5_CHO cells were plated at 20,000 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/18/2015
Entry Details
US Patent