BDBM14187 3,13-diazahexacyclo[14.8.0.0^{2,10}.0^{4,9}.0^{11,15}.0^{17,22}]tetracosa-1(16),2(10),4(9),5,7,11(15),17(22),18,20,23-decaene-12,14-dione::6H,14H-Naphthyl[3,4-a]pyrrolo[3,4-c]carbazole-5,7(5H,7H)-dione::CHEMBL332575::Imide Analog 12

SMILES O=C1NC(=O)c2c1c1c3ccccc3[nH]c1c1ccc3ccccc3c21

InChI Key InChIKey=HVVKFYHINSILFO-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 14187   

LigandPNGBDBM14187(6H,14H-Naphthyl[3,4-a]pyrrolo[3,4-c]carbazole-5,7(...)
Affinity DataIC50: 300nMpH: 7.2 T: 2°CAssay Description:The MLK1, MLK2, and MLK3 assays were performed using the Millipore multiscreen trichloroacetic acid (TCA) in-plate format. IC50 values were calculate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2007
Entry Details Article
PubMed
LigandPNGBDBM14187(6H,14H-Naphthyl[3,4-a]pyrrolo[3,4-c]carbazole-5,7(...)
Affinity DataIC50: 300nMAssay Description:The MLK1, MLK2, and MLK3 assays were performed using the Millipore multiscreen trichloroacetic acid (TCA) in-plate format. IC50 values were calculate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2007
Entry Details Article
PubMed
TargetProtein kinase C alpha type(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM14187(6H,14H-Naphthyl[3,4-a]pyrrolo[3,4-c]carbazole-5,7(...)
Affinity DataIC50: 5.28E+4nMAssay Description:Inhibition of Protein kinase C alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM14187(6H,14H-Naphthyl[3,4-a]pyrrolo[3,4-c]carbazole-5,7(...)
Affinity DataIC50: 275nMAssay Description:Inhibition of Cyclin E-cyclin-dependent kinase 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM14187(6H,14H-Naphthyl[3,4-a]pyrrolo[3,4-c]carbazole-5,7(...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of Protein kinase AMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM14187(6H,14H-Naphthyl[3,4-a]pyrrolo[3,4-c]carbazole-5,7(...)
Affinity DataIC50: 45nMAssay Description:Inhibitory activity against Cyclin D1-cyclin-dependent kinase 4 by measuring the phosphorylation of RbINGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM14187(6H,14H-Naphthyl[3,4-a]pyrrolo[3,4-c]carbazole-5,7(...)
Affinity DataIC50: 4.38E+3nMAssay Description:Inhibition of Glycogen synthase kinase-3 betaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProtein kinase C gamma type(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM14187(6H,14H-Naphthyl[3,4-a]pyrrolo[3,4-c]carbazole-5,7(...)
Affinity DataIC50: 5.65E+4nMAssay Description:Inhibition of Protein kinase C gammaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProtein kinase C beta type(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM14187(6H,14H-Naphthyl[3,4-a]pyrrolo[3,4-c]carbazole-5,7(...)
Affinity DataIC50: 9.00E+3nMAssay Description:Inhibition of Protein kinase C beta 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM14187(6H,14H-Naphthyl[3,4-a]pyrrolo[3,4-c]carbazole-5,7(...)
Affinity DataIC50: 590nMAssay Description:Inhibition of Cyclin B-cyclin-dependent kinase 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed