BDBM142122 US8933079, 149::US8933079, 150::US8933079, 9.1

SMILES COc1ccc(COc2cnn(CC(=O)c3ccc(CN(C)C)cc3C)c(=O)c2)nc1

InChI Key InChIKey=ACBKFGPDANWBLT-UHFFFAOYSA-N

Data  1 KI  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 142122   

TargetMelanin-concentrating hormone receptor 1(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM142122(US8933079, 149 | US8933079, 150 | US8933079, 9.1)
Affinity DataIC50: 28nMpH: 7.0Assay Description:Membranes from CHO/Galpha16 cells stably transfected with human hMCH-1R are resuspended using a syringe (needle 0.6x25 mm) and diluted in test buffer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2015
Entry Details
Go to US Patent

TargetMelanin-concentrating hormone receptor 1(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM142122(US8933079, 149 | US8933079, 150 | US8933079, 9.1)
Affinity DataIC50: 22nMAssay Description:Displacement of [125I]-MCH from human MCH-R1 expressed in CHO/Galpha16 cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2016
Entry Details Article
PubMed
TargetMelanin-concentrating hormone receptor 1(Rat)
Boehringer Ingelheim Pharma

Curated by ChEMBL
LigandPNGBDBM142122(US8933079, 149 | US8933079, 150 | US8933079, 9.1)
Affinity DataIC50: 18nMAssay Description:Binding affinity to rat MCH-R1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2016
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Boehringer Ingelheim Pharma

Curated by ChEMBL
LigandPNGBDBM142122(US8933079, 149 | US8933079, 150 | US8933079, 9.1)
Affinity DataIC50: 1.60E+4nMAssay Description:Inhibition of human ERG by patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2016
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Boehringer Ingelheim Pharma

Curated by ChEMBL
LigandPNGBDBM142122(US8933079, 149 | US8933079, 150 | US8933079, 9.1)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2016
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Boehringer Ingelheim Pharma

Curated by ChEMBL
LigandPNGBDBM142122(US8933079, 149 | US8933079, 150 | US8933079, 9.1)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP2C19 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2016
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Boehringer Ingelheim Pharma

Curated by ChEMBL
LigandPNGBDBM142122(US8933079, 149 | US8933079, 150 | US8933079, 9.1)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2016
Entry Details Article
PubMed
TargetCytochrome P450 2C8(Human)
Boehringer Ingelheim Pharma

Curated by ChEMBL
LigandPNGBDBM142122(US8933079, 149 | US8933079, 150 | US8933079, 9.1)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP2C8 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2016
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Boehringer Ingelheim Pharma

Curated by ChEMBL
LigandPNGBDBM142122(US8933079, 149 | US8933079, 150 | US8933079, 9.1)
Affinity DataIC50: 1.80E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2016
Entry Details Article
PubMed
TargetMelanin-concentrating hormone receptor 1(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM142122(US8933079, 149 | US8933079, 150 | US8933079, 9.1)
Affinity DataKi:  14nMAssay Description:Binding affinity to human MCH-R1 expressed in CHO/Galpha16 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2016
Entry Details Article
PubMed