BDBM143210 US9682953, 2.A-22

SMILES FC(F)(F)c1ccc(Oc2cccc(C=C3CCC(CC3)NC(=O)c3ccc(Cl)nc3)c2)nc1

InChI Key InChIKey=YZLYCAIFUUYDGI-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 143210   

TargetFatty-acid amide hydrolase 1(Human)
Advinus Therapeutics

US Patent
LigandPNGBDBM143210(US9682953, 2.A-22)
Affinity DataIC50: 5nMpH: 7.4 T: 2°CAssay Description:All reagents were purchased from Sigma-Aldrich unless specified. Human and Rat Fatty Acid Amide Hydrolase (FAAH) genes used in assay have been descri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2018
Entry Details
Go to US Patent

TargetFatty-acid amide hydrolase 1 [30-579](Rat)
Advinus Therapeutics

US Patent
LigandPNGBDBM143210(US9682953, 2.A-22)
Affinity DataIC50: 81nMpH: 7.4 T: 2°CAssay Description:All reagents were purchased from Sigma-Aldrich unless specified. Human and Rat Fatty Acid Amide Hydrolase (FAAH) genes used in assay have been descri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2018
Entry Details
Go to US Patent

TargetFatty-acid amide hydrolase 1(Human)
Advinus Therapeutics

US Patent
LigandPNGBDBM143210(US9682953, 2.A-22)
Affinity DataIC50: 5.10nMAssay Description:Inhibition of human transmembrane domain deficient FFAH expressed in Escherichia coli using AAMCA as substrate incubated for 1 min measured for 50 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetFatty-acid amide hydrolase 1 [30-579](Rat)
Advinus Therapeutics

US Patent
LigandPNGBDBM143210(US9682953, 2.A-22)
Affinity DataIC50: 81nMAssay Description:Inhibition of rat FFAH expressed in Escherichia coli using AAMCA as substrate incubated for 1 min measured for 50 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed