BDBM143333 US8969341, 1

SMILES CC(C)c1c2C(N(C(=O)c2nn1Cc1ccccn1)c1cccc(Cl)c1F)c1ccc(Cl)cc1C

InChI Key InChIKey=OPXLDTUTDCQLID-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 143333   

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Novartis

US Patent
LigandPNGBDBM143333(US8969341, 1)
Affinity DataIC50: 6.51nMAssay Description:The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/16/2015
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Novartis

US Patent
LigandPNGBDBM143333(US8969341, 1)
Affinity DataIC50: 7.80nMAssay Description:The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/16/2015
Entry Details
US Patent

TargetProtein Mdm4(Human)
Novartis

US Patent
LigandPNGBDBM143333(US8969341, 1)
Affinity DataIC50: 4.16E+3nMAssay Description:The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/16/2015
Entry Details
US Patent

TargetProtein Mdm4(Human)
Novartis

US Patent
LigandPNGBDBM143333(US8969341, 1)
Affinity DataIC50: 4.16E+3nMAssay Description:Inhibition of p53 derived Cy5-TFSDLWKLL peptide binding to human MDMX (2 to 185 residues) by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Human)
Novartis

US Patent
LigandPNGBDBM143333(US8969341, 1)
Affinity DataIC50: 7.80E+3nMAssay Description:Inhibition of p53 derived Cy5-TFSDLWKLL peptide binding to human MDM2 (2 to 188 residues) by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed