BDBM143402 US9682953, 20.A-15::US9682953, 20.A-16

SMILES FC(F)(F)c1ccc(Oc2cccc(C=C3CCC(CC3)NC(=O)c3cccnn3)c2)nc1

InChI Key InChIKey=RIMNYGJVCCUIFM-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 143402   

TargetFatty-acid amide hydrolase 1(Human)
Advinus Therapeutics

US Patent
LigandPNGBDBM143402(US9682953, 20.A-16 | US9682953, 20.A-15)
Affinity DataIC50: 431nMpH: 7.4 T: 2°CAssay Description:All reagents were purchased from Sigma-Aldrich unless specified. Human and Rat Fatty Acid Amide Hydrolase (FAAH) genes used in assay have been descri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2018
Entry Details
Go to US Patent

TargetFatty-acid amide hydrolase 1 [30-579](Rat)
Advinus Therapeutics

US Patent
LigandPNGBDBM143402(US9682953, 20.A-16 | US9682953, 20.A-15)
Affinity DataIC50: 408nMpH: 7.4 T: 2°CAssay Description:All reagents were purchased from Sigma-Aldrich unless specified. Human and Rat Fatty Acid Amide Hydrolase (FAAH) genes used in assay have been descri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2018
Entry Details
Go to US Patent

TargetFatty-acid amide hydrolase 1(Human)
Advinus Therapeutics

US Patent
LigandPNGBDBM143402(US9682953, 20.A-16 | US9682953, 20.A-15)
Affinity DataIC50: 4nMpH: 7.4 T: 2°CAssay Description:All reagents were purchased from Sigma-Aldrich unless specified. Human and Rat Fatty Acid Amide Hydrolase (FAAH) genes used in assay have been descri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2018
Entry Details
Go to US Patent

TargetFatty-acid amide hydrolase 1 [30-579](Rat)
Advinus Therapeutics

US Patent
LigandPNGBDBM143402(US9682953, 20.A-16 | US9682953, 20.A-15)
Affinity DataIC50: 115nMpH: 7.4 T: 2°CAssay Description:All reagents were purchased from Sigma-Aldrich unless specified. Human and Rat Fatty Acid Amide Hydrolase (FAAH) genes used in assay have been descri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2018
Entry Details
Go to US Patent

TargetFatty-acid amide hydrolase 1(Human)
Advinus Therapeutics

US Patent
LigandPNGBDBM143402(US9682953, 20.A-16 | US9682953, 20.A-15)
Affinity DataIC50: 9nMAssay Description:Inhibition of human transmembrane domain deficient FFAH expressed in Escherichia coli using AAMCA as substrate incubated for 1 min measured for 50 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetFatty-acid amide hydrolase 1 [30-579](Rat)
Advinus Therapeutics

US Patent
LigandPNGBDBM143402(US9682953, 20.A-16 | US9682953, 20.A-15)
Affinity DataIC50: 194nMAssay Description:Inhibition of rat FFAH expressed in Escherichia coli using AAMCA as substrate incubated for 1 min measured for 50 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed