BDBM144316 US8969336, 549::US8969336, 578

SMILES CC(C)c1nc(C(N)=O)c(Nc2ccc(cc2)N2CCC(CC2)N2CCN(C)CC2)nc1NC1CCOCC1

InChI Key InChIKey=JGCBLHLFAFWUNH-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 144316   

TargetTyrosine-protein kinase receptor(Human)
Astellas Pharma

US Patent
LigandPNGBDBM144316(US8969336, 578 | US8969336, 549)
Affinity DataIC50: 2.10nMAssay Description:A recombinant retrovirus was created from expression plasmid FLAG-EML4-ALKv1/pMX-iresCD8 in which cDNA for EMLA-ALK fusion protein v1 was integrated,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2015
Entry Details
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TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Astellas Pharma

US Patent
LigandPNGBDBM144316(US8969336, 578 | US8969336, 549)
Affinity DataIC50: 1.5nMAssay Description:A partial protein of only a kinase domain of RET protein was purchased from Carna Biosciences Inc., Japan. The phosphorylation activity toward a pept...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2015
Entry Details
Go to US Patent

TargetProto-oncogene tyrosine-protein kinase ROS(Human)
Astellas Pharma

US Patent
LigandPNGBDBM144316(US8969336, 578 | US8969336, 549)
Affinity DataIC50: 0.510nMAssay Description:A partial protein of only a kinase domain of ROS protein was purchased from Carna Biosciences Inc., Japan, and tests were conducted as in Test Exampl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2015
Entry Details
Go to US Patent

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Astellas Pharma

US Patent
LigandPNGBDBM144316(US8969336, 578 | US8969336, 549)
Affinity DataIC50: 0.560nMAssay Description:A partial protein of only a kinase domain of FLT3 protein was purchased from Carna Biosciences Inc., Japan, and tests were conducted as in Test Examp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2015
Entry Details
Go to US Patent