BDBM14543 2-[6-(3-aminophenyl)-5-chloro-3-(cyclobutylamino)-2-oxo-1,2-dihydropyrazin-1-yl]-N-[(4-carbamimidoylphenyl)methyl]acetamide::CHEMBL77490::Pyrazinone Analog 29f

SMILES NC(=N)c1ccc(CNC(=O)Cn2c(c(Cl)nc(NC3CCC3)c2=O)-c2cccc(N)c2)cc1

InChI Key InChIKey=QTEZLPKXQWGAMA-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 14543   

TargetProthrombin(Human)
Pharmacia

LigandPNGBDBM14543(2-[6-(3-aminophenyl)-5-chloro-3-(cyclobutylamino)-...)
Affinity DataIC50: 8.00E+3nMAssay Description:Recombinant human Factor VIIa and soluble tissue factor were added to a 96-well assay plate containing substrate and inhibitor in reaction buffer. Th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/2/2007
Entry Details Article
PubMed
TargetCoagulation factor VII(Human)
Pharmacia

LigandPNGBDBM14543(2-[6-(3-aminophenyl)-5-chloro-3-(cyclobutylamino)-...)
Affinity DataIC50: 20nMAssay Description:Recombinant human Factor VIIa and soluble tissue factor were added to a 96-well assay plate containing substrate and inhibitor in reaction buffer. Th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/2/2007
Entry Details Article
PubMed
TargetProthrombin(Human)
Pharmacia

LigandPNGBDBM14543(2-[6-(3-aminophenyl)-5-chloro-3-(cyclobutylamino)-...)
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibitory activity against ThrombinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Pharmacia

Curated by ChEMBL
LigandPNGBDBM14543(2-[6-(3-aminophenyl)-5-chloro-3-(cyclobutylamino)-...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibitory activity against coagulation factor XMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSerine protease 1(Human)
Pharmacia

Curated by ChEMBL
LigandPNGBDBM14543(2-[6-(3-aminophenyl)-5-chloro-3-(cyclobutylamino)-...)
Affinity DataIC50: 32nMAssay Description:Inhibitory activity against trypsinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProthrombin(Human)
Pharmacia

LigandPNGBDBM14543(2-[6-(3-aminophenyl)-5-chloro-3-(cyclobutylamino)-...)
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibition of human thrombin using H-D-phenylalanyl-L-pipecolyl-L-arginine-p-nitroaniline dihydrochloride as substrate after 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetCoagulation factor VII/Tissue factor(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM14543(2-[6-(3-aminophenyl)-5-chloro-3-(cyclobutylamino)-...)
Affinity DataIC50: 20nMAssay Description:Inhibition of recombinant soluble tissue factor (unknown origin)/recombinant human factor 7a using N-methylsulfonyl-D-phe-gly arg-p-nitroaniline as s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed