BDBM146225 US8957068, 277

SMILES CC(C)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2ccc(cc2)-c2ccccn2)n1

InChI Key InChIKey=LMAOMLHBKRXYLM-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 146225   

TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Human)
Novartis

US Patent
LigandPNGBDBM146225(US8957068, 277)
Affinity DataIC50: 89.9nMpH: 7.5 T: 2°CAssay Description:The IDH1 (R132H) mutant catalyzes the reduced form of NADP+ (NADPH) and α-ketoglutarate (α-KG) to form nicotinamide adenine dinucleotide ph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2015
Entry Details
US Patent

TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Human)
Novartis

US Patent
LigandPNGBDBM146225(US8957068, 277)
Affinity DataIC50: 94nMAssay Description:Inhibition of IDH1 R132H mutant (unknown origin) using alphaKG as substrate after 45 mins by LC-MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Human)
Novartis

US Patent
LigandPNGBDBM146225(US8957068, 277)
Affinity DataIC50: 94nMpH: 7.4 T: 2°CAssay Description:Mutant IDH1 R132H catalytic activity was monitored using the quantitative liquid chromatography/mass spectrometry (LC-MS) detection of 2-HG, a produc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2015
Entry Details
US Patent