BDBM1468 4-({3-[cyclopropyl({4-hydroxy-2-oxo-2H,5H,6H,7H,8H,9H,10H-cycloocta[b]pyran-3-yl})methyl]phenyl}sulfamoyl)benzoic acid::Sulfonamide-Substituted Cyclooctylpyranone deriv. 35m

SMILES OC(=O)c1ccc(cc1)S(=O)(=O)Nc1cccc(c1)C(C1CC1)c1c(O)c2CCCCCCc2oc1=O

InChI Key InChIKey=AQDZSPFFMWBAMX-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 1468   

TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Upjohn

LigandPNGBDBM1468(4-({3-[cyclopropyl({4-hydroxy-2-oxo-2H,5H,6H,7H,8H...)
Affinity DataKi:  11nMAssay Description:HIV-1 protease was purified and refolded from E. coli inclusion bodies. The substrate used spans the p17-p24 processing site (R-V-S-Q-N-Y-P-I-V-Q-N-K...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2004
Entry Details Article
PubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM1468(4-({3-[cyclopropyl({4-hydroxy-2-oxo-2H,5H,6H,7H,8H...)
Affinity DataKi:  11nMAssay Description:Inhibition of HIV-1 protease.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2010
Entry Details Article