BDBM148431 US8962637, 162

SMILES CN1CCN(CC1)c1ccc(Nc2ncc3C(=O)N(CCc3n2)c2cc(NC(=O)c3cccc(c3)C(F)(F)F)ccc2Cl)cc1

InChI Key InChIKey=SGLDXZLAQLSXFP-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 148431   

TargetTyrosine-protein kinase JAK2(Human)
Debiopharm

US Patent
LigandPNGBDBM148431(US8962637, 162)
Affinity DataIC50: 6nMAssay Description:Compounds were screened in the TR-FRET assay for JAK2 and c-Src kinase inhibition. Ultra light poly GT (Perkin Elmer) was used as the substrate for J...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2015
Entry Details
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TargetProto-oncogene tyrosine-protein kinase Src(Human)
Debiopharm

US Patent
LigandPNGBDBM148431(US8962637, 162)
Affinity DataIC50: 27nMAssay Description:Compounds were screened in the TR-FRET assay for JAK2 and c-Src kinase inhibition. Ultra light poly GT (Perkin Elmer) was used as the substrate for J...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2015
Entry Details
Go to US Patent