BDBM148436 US8962637, 167

SMILES CN1CCN(CC1)C(=O)c1ccc(Nc2ncc3CN(CCc3n2)c2cc(NC(=O)c3cc(ccn3)C(F)(F)F)ccc2C)cc1

InChI Key InChIKey=RPKWQQFQJOCDPR-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 148436   

TargetTyrosine-protein kinase JAK2(Human)
Debiopharm

US Patent
LigandPNGBDBM148436(US8962637, 167)
Affinity DataIC50: 5.30nMAssay Description:Compounds were screened in the TR-FRET assay for JAK2 and c-Src kinase inhibition. Ultra light poly GT (Perkin Elmer) was used as the substrate for J...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2015
Entry Details
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TargetProto-oncogene tyrosine-protein kinase Src(Human)
Debiopharm

US Patent
LigandPNGBDBM148436(US8962637, 167)
Affinity DataIC50: 27nMAssay Description:Compounds were screened in the TR-FRET assay for JAK2 and c-Src kinase inhibition. Ultra light poly GT (Perkin Elmer) was used as the substrate for J...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2015
Entry Details
Go to US Patent