BDBM149711 US8975409, Comparative compound B

SMILES CCC(CC)CC1(O)CCN(CC1)C(=O)Nc1cccc(Oc2ccc(F)cc2)c1

InChI Key InChIKey=QDTNDGDKXXSUJU-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 149711   

TargetSphingosine 1-phosphate receptor 2(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM149711(US8975409, Comparative compound B)
Affinity DataIC50: 1.20E+3nMpH: 7.2 T: 2°CAssay Description:Chinese hamster ovary (CHO) cells overexpressing the human S1P2 gene were cultured in a Ham's F12 medium containing 10% fetal bovine serum (FBS), an ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/10/2015
Entry Details
Go to US Patent

TargetSphingosine 1-phosphate receptor 2(Rat)
Ono Pharmaceutical

US Patent
LigandPNGBDBM149711(US8975409, Comparative compound B)
Affinity DataIC50: 27nMpH: 7.2 T: 2°CAssay Description:Chinese hamster ovary (CHO) cells overexpressing the human S1P2 gene were cultured in a Ham's F12 medium containing 10% fetal bovine serum (FBS), an ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/10/2015
Entry Details
Go to US Patent

TargetSphingosine 1-phosphate receptor 2(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM149711(US8975409, Comparative compound B)
Affinity DataIC50: 1.20E+3nMAssay Description:Antagonist activity at human S1P2 receptor overexpressed in CHO cells assessed as increase in intracellular calcium ion concentration incubated 3 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2016
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 2(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM149711(US8975409, Comparative compound B)
Affinity DataIC50: 1.20E+3nMAssay Description:Displacement of [33P]-S1P from human S1P2 receptor expressed in CHOK1 cells after 60 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2016
Entry Details Article
PubMed