BDBM149712 US8975409, Example 9

SMILES CC(C)CC1(O)CCN(CC1)C(=O)Nc1cc(Oc2ccc(F)cc2)cc(Oc2ccc(cc2)C(C)(C)C(O)=O)c1

InChI Key InChIKey=MBTKFRQXHPGCLC-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 149712   

TargetSphingosine 1-phosphate receptor 2(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM149712(US8975409, Example 9)
Affinity DataIC50: 2.30nMpH: 7.2 T: 2°CAssay Description:Chinese hamster ovary (CHO) cells overexpressing the human S1P2 gene were cultured in a Ham's F12 medium containing 10% fetal bovine serum (FBS), an ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/10/2015
Entry Details
Go to US Patent

TargetSphingosine 1-phosphate receptor 2(Rat)
Ono Pharmaceutical

US Patent
LigandPNGBDBM149712(US8975409, Example 9)
Affinity DataIC50: 2.5nMpH: 7.2 T: 2°CAssay Description:Chinese hamster ovary (CHO) cells overexpressing the human S1P2 gene were cultured in a Ham's F12 medium containing 10% fetal bovine serum (FBS), an ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/10/2015
Entry Details
Go to US Patent

TargetSphingosine 1-phosphate receptor 2(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM149712(US8975409, Example 9)
Affinity DataIC50: 2.30nMAssay Description:Antagonist activity at S1P2 receptor (unknown origin) expressed in CHO cells assessed as inhibition of S1P-induced increase in intracellular calcium ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2017
Entry Details Article
PubMed